6oww
From Proteopedia
(Difference between revisions)
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==Crystal structure of a Human Cardiac Calsequestrin Filament Complexed with Ytterbium== | ==Crystal structure of a Human Cardiac Calsequestrin Filament Complexed with Ytterbium== | ||
| - | <StructureSection load='6oww' size='340' side='right'caption='[[6oww]]' scene=''> | + | <StructureSection load='6oww' size='340' side='right'caption='[[6oww]], [[Resolution|resolution]] 3.84Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OWW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6OWW FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6oww]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OWW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6OWW FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6oww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oww OCA], [http://pdbe.org/6oww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oww RCSB], [http://www.ebi.ac.uk/pdbsum/6oww PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oww ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6owv|6owv]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASQ2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6oww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oww OCA], [http://pdbe.org/6oww PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oww RCSB], [http://www.ebi.ac.uk/pdbsum/6oww PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oww ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CASQ2_HUMAN CASQ2_HUMAN]] Defects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2) [MIM:[http://omim.org/entry/611938 611938]]; also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death.<ref>PMID:17881003</ref> <ref>PMID:11704930</ref> <ref>PMID:15485681</ref> <ref>PMID:16908766</ref> <ref>PMID:18399795</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CASQ2_HUMAN CASQ2_HUMAN]] Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions.<ref>PMID:17881003</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Deiter | + | [[Category: Deiter, F H]] |
| - | [[Category: Deo | + | [[Category: Deo, R C]] |
| - | [[Category: Jura N]] | + | [[Category: Jura, N]] |
| - | [[Category: Shi C]] | + | [[Category: Shi, C]] |
| - | [[Category: Titus | + | [[Category: Titus, E W]] |
| + | [[Category: Calcium-binding protein]] | ||
| + | [[Category: Calsequestrin]] | ||
| + | [[Category: Metal binding protein]] | ||
| + | [[Category: Sarcoplasmic reticulum protein]] | ||
Revision as of 06:09, 14 October 2020
Crystal structure of a Human Cardiac Calsequestrin Filament Complexed with Ytterbium
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