Moesin

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== Structural highlights ==
== Structural highlights ==
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The 3D structure of the complex between FERM domain of the actin-binding moesin and the C-tail domain of cell polarity protein Crumbs shows that the interaction between the 2 proteins involves <scene name='86/864718/Cv/2'>very few residues</scene><ref>PMID:25792740</ref>.
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The 3D structure of the complex between FERM domain of the actin-binding moesin and the C-tail domain of cell polarity protein Crumbs shows that the interaction between the 2 proteins involves <scene name='86/864718/Cv/3'>very few residues</scene><ref>PMID:25792740</ref>.
</StructureSection>
</StructureSection>

Revision as of 14:20, 15 October 2020

Mouse moesin FERM domain (green) complex with Crumbs C-terminal peptide (magenta), glycerol and I- ions (purple) (PDB code 4yl8).

Drag the structure with the mouse to rotate

3D structures of moesin

Updated on 15-October-2020

3u8z - hMO FERM domain 1-296 - human
1ef1 - hMO FERM domain + C-terminal domain 487-576
1e5w - hMO FERM domain + 1st helix 297-345
6txq - hMO FERM+helical linker domains - Cryo EM
6txs - hMO FERM+helical linker domains + CD44 peptide
1sgh - hMO FERM domain + EBP50 peptide
2i1k, 2i1j - MO - armyworm
4yl8 - MO FERM domain + Crumbs C-terminal peptide - mouse

References

  1. ↑ Ansa-Addo EA, Zhang Y, Yang Y, Hussey GS, Howley BV, Salem M, Riesenberg B, Sun S, Rockey DC, Karvar S, Howe PH, Liu B, Li Z. Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-beta signaling. J Clin Invest. 2017 Apr 3;127(4):1321-1337. doi: 10.1172/JCI89281. Epub 2017 Mar , 13. PMID:28287407 doi:http://dx.doi.org/10.1172/JCI89281
  2. ↑ Freymuth PS, Fitzsimons HL. The ERM protein Moesin is essential for neuronal morphogenesis and long-term memory in Drosophila. Mol Brain. 2017 Aug 29;10(1):41. doi: 10.1186/s13041-017-0322-y. PMID:28851405 doi:http://dx.doi.org/10.1186/s13041-017-0322-y
  3. ↑ Karvar S, Ansa-Addo EA, Suda J, Singh S, Zhu L, Li Z, Rockey DC. Moesin, an Ezrin/Radixin/Moesin Family Member, Regulates Hepatic Fibrosis. Hepatology. 2019 Dec 20. doi: 10.1002/hep.31078. PMID:31860744 doi:http://dx.doi.org/10.1002/hep.31078
  4. ↑ Wei Z, Li Y, Ye F, Zhang M. Structural basis for the phosphorylation-regulated interaction between the cytoplasmic tail of cell polarity protein Crumbs and the actin binding protein Moesin. J Biol Chem. 2015 Mar 19. pii: jbc.M115.643791. PMID:25792740 doi:http://dx.doi.org/10.1074/jbc.M115.643791

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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