Ras-related protein Rab
From Proteopedia
(Difference between revisions)
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Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene> between its inactive GDP-bound structure and its active GTP-bound structure. <scene name='80/804492/Cv/8'>GDP forms numerous interactions at the active site</scene> located at the surface of the protein<ref>PMID:14699104</ref>. Water molecules are shown as red spheres. | Rab-11A undergoes a conformation change of <scene name='80/804492/Cv/2'>two switch regions</scene> between its inactive GDP-bound structure and its active GTP-bound structure. <scene name='80/804492/Cv/8'>GDP forms numerous interactions at the active site</scene> located at the surface of the protein<ref>PMID:14699104</ref>. Water molecules are shown as red spheres. | ||
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| + | [[3D structures of Ras-related protein Rab]] | ||
</StructureSection> | </StructureSection> | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *Rab-1 | + | *Rab-1 GTPase domain 1-178 |
**[[2fol]] – hRab-1 + GDP - human<br /> | **[[2fol]] – hRab-1 + GDP - human<br /> | ||
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**[[3sfv]] – hRab-1 (mutant) + LidA + GDP<br /> | **[[3sfv]] – hRab-1 (mutant) + LidA + GDP<br /> | ||
**[[3nkv]] – hRab-1 + GNP + AMP<br /> | **[[3nkv]] – hRab-1 + GNP + AMP<br /> | ||
| - | **[[3jza]] – hRab-1 + DrrA <br /> | + | **[[3jza]], [[2wwx]], [[3l0i]] – hRab-1 + DrrA <br /> |
**[[5o74]] – hRab-1 + DrrA + GDP <br /> | **[[5o74]] – hRab-1 + DrrA + GDP <br /> | ||
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**[[2gf9]] – hRab-3 + GDP <br /> | **[[2gf9]] – hRab-3 + GDP <br /> | ||
| - | **[[ | + | **[[3rab]] – Rab-3 + GNP - rat<br /> |
| + | **[[4rkf]] – DmRab-3 + GDP - ''Drosophila melanogaster''<br /> | ||
*Rab-4 | *Rab-4 | ||
**[[2o52]] – hRab-4 + GDP<br /> | **[[2o52]] – hRab-4 + GDP<br /> | ||
| + | **[[1yu9]] – hRab-4 + GNP<br /> | ||
*Rab-5C | *Rab-5C | ||
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**[[1z02]] – mRab-5C (mutant) + GNP - mouse<br /> | **[[1z02]] – mRab-5C (mutant) + GNP - mouse<br /> | ||
**[[1z0d]], [[1z0a]] – mRab-5C + GDP <br /> | **[[1z0d]], [[1z0a]] – mRab-5C + GDP <br /> | ||
| + | **[[1huq]] – mRab-5C + GNP <br /> | ||
*Rab-6 | *Rab-6 | ||
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**[[2ffq]] – hRab-6 + GSP <br /> | **[[2ffq]] – hRab-6 + GSP <br /> | ||
**[[2gil]] – hRab-6 + GTP <br /> | **[[2gil]] – hRab-6 + GTP <br /> | ||
| + | **[[1yzq]] – hRab-6 + GNP <br /> | ||
**[[3bbp]] – hRab-6 + GCC185 + GTP <br /> | **[[3bbp]] – hRab-6 + GCC185 + GTP <br /> | ||
**[[3cwz]] – mRab-6 + R6IP1 + GTP <br /> | **[[3cwz]] – mRab-6 + R6IP1 + GTP <br /> | ||
**[[5lef]] – mRab-6 + KIF20A + GTP <br /> | **[[5lef]] – mRab-6 + KIF20A + GTP <br /> | ||
| + | **[[2y8e]] – DmRab-5C + GNP <br /> | ||
*Rab-7L1 | *Rab-7L1 | ||
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**[[5c46]] – hRab-11A (mutant) + PI4KB + GDPγS<br /> | **[[5c46]] – hRab-11A (mutant) + PI4KB + GDPγS<br /> | ||
**[[5c4g]], [[5euq]], [[4d0l]] – hRab-11A (mutant) + PI4KB + GDPγS + inhibitor<br /> | **[[5c4g]], [[5euq]], [[4d0l]] – hRab-11A (mutant) + PI4KB + GDPγS + inhibitor<br /> | ||
| + | |||
| + | *Rab-11B | ||
| + | |||
| + | **[[2f9l]] – hRab-11B + GDP <br /> | ||
| + | **[[2f9m]] – hRab-11B + GNP <br /> | ||
| + | |||
| + | *Rab-12 | ||
| + | |||
| + | **[[2il1]] – hRab-12 + GDP <br /> | ||
*Rab-14 | *Rab-14 | ||
**[[4d0g]] – hRab-14 (mutant) + Rab11 family-interacting protein 1 <br /> | **[[4d0g]] – hRab-14 (mutant) + Rab11 family-interacting protein 1 <br /> | ||
| - | **[[4drz]] – hRab-14 + GDP <br /> | + | **[[4drz]], [[1z0f]] – hRab-14 + GDP <br /> |
*Rab-18 | *Rab-18 | ||
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*Rab-33 | *Rab-33 | ||
| - | **[[1z06]] – mRab-33 + Gyp1 | + | **[[1z06]] – mRab-33 + Gyp1 + GDP <br /> |
| - | + | ||
**[[2g77]] – mRab-33 + GNP <br /> | **[[2g77]] – mRab-33 + GNP <br /> | ||
**[[6zay]] – mRab-33 + Atg16L + GDP <br /> | **[[6zay]] – mRab-33 + Atg16L + GDP <br /> | ||
Revision as of 08:20, 18 October 2020
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3D structures of Ras-related protein Rab
Updated on 18-October-2020
References
- ↑ Bhuin T, Roy JK. Rab11 in disease progression. Int J Mol Cell Med. 2015 Winter;4(1):1-8. PMID:25815277
- ↑ Pasqualato S, Senic-Matuglia F, Renault L, Goud B, Salamero J, Cherfils J. The structural GDP/GTP cycle of Rab11 reveals a novel interface involved in the dynamics of recycling endosomes. J Biol Chem. 2004 Mar 19;279(12):11480-8. Epub 2003 Dec 29. PMID:14699104 doi:10.1074/jbc.M310558200
