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5y6k

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Revision as of 09:12, 21 October 2020

Human serum trnasferrin bound to a fluorescent probe

Structural highlights

5y6k is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[TRFE_HUMAN] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.^[1] ^[2]

Function

[TRFE_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

Publication Abstract from PubMed

Porphyromonas gingivalis is a key oral anaerobic bacterium involved in human periodontitis, which may affect up to 15% adults worldwide. Using the membrane permeable fluorescent probe Fe-TRACER, we identified 17 iron-associated proteins in Porphyromonas gingivalis. We demonstrated the specific binding of the probe towards iron-associated proteins using transferrin as an example and provided an X-ray structure of the fluorescent probe-bound transferrin. Our study provides a basis for the understanding of iron homeostasis in pathogens, and our approach based on the integration of fluorescence imaging with proteomics and bioinformatics can be readily extended to mine other metalloproteomes in microbials.

Tracking iron-associated proteomes in pathogens by a fluorescence approach.,Jiang N, Cheng T, Wang M, Chan GC, Jin L, Li H, Sun H Metallomics. 2018 Jan 11. doi: 10.1039/c7mt00275k. PMID:29323384^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Beutler E, Gelbart T, Lee P, Trevino R, Fernandez MA, Fairbanks VF. Molecular characterization of a case of atransferrinemia. Blood. 2000 Dec 15;96(13):4071-4. PMID:11110675
↑ Knisely AS, Gelbart T, Beutler E. Molecular characterization of a third case of human atransferrinemia. Blood. 2004 Oct 15;104(8):2607. PMID:15466165 doi:10.1182/blood-2004-05-1751
↑ Jiang N, Cheng T, Wang M, Chan GC, Jin L, Li H, Sun H. Tracking iron-associated proteomes in pathogens by a fluorescence approach. Metallomics. 2018 Jan 11. doi: 10.1039/c7mt00275k. PMID:29323384 doi:http://dx.doi.org/10.1039/c7mt00275k

1 Structural highlights
2 Disease
3 Function
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5y6k"

@@ Line 1: / Line 1: @@
 ==Human serum trnasferrin bound to a fluorescent probe==
-<StructureSection load='5y6k' size='340' side='right' caption='[[5y6k]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
+<StructureSection load='5y6k' size='340' side='right'caption='[[5y6k]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5y6k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y6K FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5y6k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y6K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5Y6K FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8R6:(2S)-6-[2-(7-azido-4-methyl-2-oxidanylidene-chromen-3-yl)ethanoylamino]-2-[bis(2-hydroxy-2-oxoethyl)amino]hexanoic+acid'>8R6</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8R6:(2S)-6-[2-(7-azido-4-methyl-2-oxidanylidene-chromen-3-yl)ethanoylamino]-2-[bis(2-hydroxy-2-oxoethyl)amino]hexanoic+acid'>8R6</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y6k OCA], [http://pdbe.org/5y6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y6k RCSB], [http://www.ebi.ac.uk/pdbsum/5y6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y6k ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5y6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y6k OCA], [http://pdbe.org/5y6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y6k RCSB], [http://www.ebi.ac.uk/pdbsum/5y6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y6k ProSAT]</span></td></tr>
 </table>
 == Disease ==
@@ Line 20: / Line 20: @@
 </div>
 <div class="pdbe-citations 5y6k" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Transferrin 3D structures|Transferrin 3D structures]]
 == References ==
 <references/>
@@ Line 25: / Line 28: @@
 </StructureSection>
 [[Category: Homo sapiens]]
+[[Category: Large Structures]]
 [[Category: Chan, G C.F]]
 [[Category: Cheng, T]]

5y6k

From Proteopedia

Revision as of 09:12, 21 October 2020

Human serum trnasferrin bound to a fluorescent probe

Structural highlights

Disease

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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