1cvz

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[[Image:1cvz.gif|left|200px]]
[[Image:1cvz.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1cvz |SIZE=350|CAPTION= <scene name='initialview01'>1cvz</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1cvz", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=C48:N1-(1-DIMETHYLCARBAMOYL-2-PHENYL-ETHYL)-2-OXO-N4-(2-PYRIDIN-2-YL-ETHYL)-SUCCINAMIDE'>C48</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Papain Papain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1cvz| PDB=1cvz | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cvz OCA], [http://www.ebi.ac.uk/pdbsum/1cvz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cvz RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)'''
'''CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Tsuge, H.]]
[[Category: Tsuge, H.]]
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[[Category: cathepsin l inhibitor]]
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[[Category: Cathepsin l inhibitor]]
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[[Category: clik148]]
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[[Category: Clik148]]
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[[Category: papain]]
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[[Category: Papain]]
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[[Category: sulfhydryl proteinase]]
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[[Category: Sulfhydryl proteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:10:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:29:34 2008''
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Revision as of 10:10, 2 May 2008

Image:1cvz.gif

Template:STRUCTURE 1cvz

CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)


Overview

Papain was used as an experimental model structure to understand the inhibition mechanism of newly developed specific inhibitors of cathepsin L, the papain superfamily. Recently, we developed a series of cathepsin L-specific inhibitors which are called the CLIK series [(1999) FEBS Lett. 458, 6-10]. Here, we report the complex structure of papain with CLIK148, which is a representative inhibitor from the CLIK series. The inhibitor complex structure was solved at 1.7 A resolution with conventional R 0.177. Unlike other epoxisuccinate inhibitors (E64, CA030, and CA074), CLIK148 uses both prime and nonprime sites, which are important for the specific inhibitory effect on cathepsin L. Also, the specificity for cathepsin L could be explained by the existence of Phe in the P2 site and hydrophobic interaction of N-terminal pyridine ring.

About this Structure

1CVZ is a Single protein structure of sequence from Carica papaya. Full crystallographic information is available from OCA.

Reference

Inhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complex., Tsuge H, Nishimura T, Tada Y, Asao T, Turk D, Turk V, Katunuma N, Biochem Biophys Res Commun. 1999 Dec 20;266(2):411-6. PMID:10600517 Page seeded by OCA on Fri May 2 13:10:12 2008

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