Ribozyme

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*Group I intron ribozymes
*Group I intron ribozymes
-
**[[1u6b]], [[1zzn]], [[3bo2]], [[3bo3]], [[3bo4]], and [[3iin]] - ''Azoarcus'' group I intron <br/>
+
**[[1u6b]], [[1zzn]], [[3bo2]], [[3bo3]], [[3bo4]], [[3iin]] - RZ P9 + RNA + U1 small nuclear ribonucleoprotein <br/>
**[[2r8s]] – RZ P4-P6 domain + antibody – mouse<BR />
**[[2r8s]] – RZ P4-P6 domain + antibody – mouse<BR />
**[[1y0q]] – RZ group I + RNA – Staphylococcus phage twort<BR />
**[[1y0q]] – RZ group I + RNA – Staphylococcus phage twort<BR />
Line 95: Line 95:
**[[1l8v]], [[1gid]] – TtRZ P4-P6 domain<BR />
**[[1l8v]], [[1gid]] – TtRZ P4-P6 domain<BR />
**[[1hr2]] - TtRZ P4-P6 domain (mutant) <BR />
**[[1hr2]] - TtRZ P4-P6 domain (mutant) <BR />
 +
**[[3hhn]] – ligase RZ + U1 small nuclear ribonucleoprotein A<BR />
 +
**[[3r1h]], [[3r1l]] - ligase RZ (mutant) + U1 small nuclear ribonucleoprotein A+ RNA<br />
*Group II intron ribozymes
*Group II intron ribozymes
-
**[[5j01]], [[5j02]] - RZ - ''Oceanobacillus iheyensis'' <br/>
 
**[[6ez0]] – yRZ - NMR<BR />
**[[6ez0]] – yRZ - NMR<BR />
 +
**[[5j01]], [[5j02]] - OiRZ - ''Oceanobacillus iheyensis'' <br/>
 +
**[[6t3k]], [[6t3n]], [[6t3r]], [[6t3s]] - OiRZ (mutant) <br/>
 +
**[[3fs0]], [[3ftm]] - ligase RZ<br />
*Various ribozymes
*Various ribozymes

Revision as of 10:58, 26 October 2020

Hammerhead ribozyme, (PDB-ID 379d)

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3D Structures of Ribozymes

Updated on 26-October-2020

References

  1. Tang J, Breaker RR. Rational design of allosteric ribozymes. Chem Biol. 1997 Jun;4(6):453-9. PMID:9224568
  2. Amarzguioui M, Prydz H. Hammerhead ribozyme design and application. Cell Mol Life Sci. 1998 Nov;54(11):1175-202. PMID:9849614 doi:http://dx.doi.org/10.1007/s000180050247
  3. Cech TR. Self-splicing of group I introns. Annu Rev Biochem. 1990;59:543-68. PMID:2197983 doi:http://dx.doi.org/10.1146/annurev.bi.59.070190.002551
  4. Roth A, Weinberg Z, Chen AG, Kim PB, Ames TD, Breaker RR. A widespread self-cleaving ribozyme class is revealed by bioinformatics. Nat Chem Biol. 2014 Jan;10(1):56-60. doi: 10.1038/nchembio.1386. Epub 2013 Nov, 17. PMID:24240507 doi:http://dx.doi.org/10.1038/nchembio.1386
  5. Weinberg Z, Kim PB, Chen TH, Li S, Harris KA, Lunse CE, Breaker RR. New classes of self-cleaving ribozymes revealed by comparative genomics analysis. Nat Chem Biol. 2015 Aug;11(8):606-10. doi: 10.1038/nchembio.1846. Epub 2015 Jul, 13. PMID:26167874 doi:http://dx.doi.org/10.1038/nchembio.1846

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