1cwv

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[[Image:1cwv.jpg|left|200px]]
[[Image:1cwv.jpg|left|200px]]
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{{Structure
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|PDB= 1cwv |SIZE=350|CAPTION= <scene name='initialview01'>1cwv</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1cwv", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>
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{{STRUCTURE_1cwv| PDB=1cwv | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cwv OCA], [http://www.ebi.ac.uk/pdbsum/1cwv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cwv RCSB]</span>
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'''CRYSTAL STRUCTURE OF INVASIN: A BACTERIAL INTEGRIN-BINDING PROTEIN'''
'''CRYSTAL STRUCTURE OF INVASIN: A BACTERIAL INTEGRIN-BINDING PROTEIN'''
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[[Category: Bjorkman, P J.]]
[[Category: Bjorkman, P J.]]
[[Category: Hamburger, Z A.]]
[[Category: Hamburger, Z A.]]
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[[Category: integrin-binding protein]]
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[[Category: Integrin-binding protein]]
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[[Category: inv gene]]
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[[Category: Inv gene]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:12:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:30:12 2008''
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Revision as of 10:12, 2 May 2008

Image:1cwv.jpg

Template:STRUCTURE 1cwv

CRYSTAL STRUCTURE OF INVASIN: A BACTERIAL INTEGRIN-BINDING PROTEIN


Overview

The Yersinia pseudotuberculosis invasin protein promotes bacterial entry by binding to host cell integrins with higher affinity than natural substrates such as fibronectin. The 2.3 angstrom crystal structure of the invasin extracellular region reveals five domains that form a 180 angstrom rod with structural similarities to tandem fibronectin type III domains. The integrin-binding surfaces of invasin and fibronectin include similarly located key residues, but in the context of different folds and surface shapes. The structures of invasin and fibronectin provide an example of convergent evolution, in which invasin presents an optimized surface for integrin binding, in comparison with host substrates.

About this Structure

1CWV is a Single protein structure of sequence from Yersinia pseudotuberculosis. Full crystallographic information is available from OCA.

Reference

Crystal structure of invasin: a bacterial integrin-binding protein., Hamburger ZA, Brown MS, Isberg RR, Bjorkman PJ, Science. 1999 Oct 8;286(5438):291-5. PMID:10514372 Page seeded by OCA on Fri May 2 13:12:00 2008

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