6y62
From Proteopedia
(Difference between revisions)
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==Crystal structure of the envelope glycoprotein complex of Maporal virus in a prefusion conformation== | ==Crystal structure of the envelope glycoprotein complex of Maporal virus in a prefusion conformation== | ||
| - | <StructureSection load='6y62' size='340' side='right'caption='[[6y62]]' scene=''> | + | <StructureSection load='6y62' size='340' side='right'caption='[[6y62]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y62 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y62 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6y62]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Maporal_virus Maporal virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y62 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y62 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y62 OCA], [http://pdbe.org/6y62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y62 RCSB], [http://www.ebi.ac.uk/pdbsum/6y62 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y62 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y62 OCA], [http://pdbe.org/6y62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y62 RCSB], [http://www.ebi.ac.uk/pdbsum/6y62 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y62 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Hantaviruses are rodent-borne viruses causing serious zoonotic outbreaks worldwide for which no treatment is available. Hantavirus particles are pleomorphic and display a characteristic square surface lattice. The envelope glycoproteins Gn and Gc form heterodimers that further assemble into tetrameric spikes, the lattice building blocks. The glycoproteins, which are the sole targets of neutralizing antibodies, drive virus entry via receptor-mediated endocytosis and endosomal membrane fusion. Here we describe the high-resolution X-ray structures of the heterodimer of Gc and the Gn head and of the homotetrameric Gn base. Docking them into an 11.4-A-resolution cryoelectron tomography map of the hantavirus surface accounted for the complete extramembrane portion of the viral glycoprotein shell and allowed a detailed description of the surface organization of these pleomorphic virions. Our results, which further revealed a built-in mechanism controlling Gc membrane insertion for fusion, pave the way for immunogen design to protect against pathogenic hantaviruses. | ||
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| + | The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism.,Serris A, Stass R, Bignon EA, Muena NA, Manuguerra JC, Jangra RK, Li S, Chandran K, Tischler ND, Huiskonen JT, Rey FA, Guardado-Calvo P Cell. 2020 Sep 9. pii: S0092-8674(20)31064-3. doi: 10.1016/j.cell.2020.08.023. PMID:32937107<ref>PMID:32937107</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6y62" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Guardado-Calvo P]] | + | [[Category: Maporal virus]] |
| - | [[Category: Rey | + | [[Category: Guardado-Calvo, P]] |
| - | [[Category: Serris A]] | + | [[Category: Rey, F A]] |
| + | [[Category: Serris, A]] | ||
| + | [[Category: Class-ii fusion protein hantavirus bunyavirus]] | ||
| + | [[Category: Prefusion complex]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 20:52, 28 October 2020
Crystal structure of the envelope glycoprotein complex of Maporal virus in a prefusion conformation
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