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5z2q

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Revision as of 21:13, 28 October 2020

Vgll1-TEAD4 core complex

Structural highlights

5z2q is a 4 chain structure. This structure supersedes the now removed PDB entry 4eaz. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TEAD4_MOUSE] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif (By similarity). Might play a role in the embryonic development of skeletal muscle. [VGLL1_MOUSE] May act as a specific coactivator for the mammalian TEFs (By similarity).

Publication Abstract from PubMed

The structure of the complex between the transcription cofactor Vgll1 and the transcription factor TEAD4, the mammalian equivalent of the Drosophila Vestigial and Scalloped, respectively, is determined in this study. Remarkably, Vgll1 interacts with TEAD in a manner similar to the transcription coactivators, as well as oncogenes YAP and TAZ, despite having a varied primary sequence. Vgll1-TEAD complex upregulates the expression of IGFBP-5, a proliferation-promoting gene, and facilitates anchorage-independent cell proliferation. The YAP/TAZ-TEAD complex also upregulates several other proliferation-promoting genes and also promotes anchorage-independent cell proliferation. Given its structural and functional similarity to YAP/TAZ, Vgll1 has the potential to promote cancer progression.

Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes.,Pobbati AV, Chan SW, Lee I, Song H, Hong W Structure. 2012 Jul 3;20(7):1135-40. Epub 2012 May 24. PMID:22632831^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Pobbati AV, Chan SW, Lee I, Song H, Hong W. Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes. Structure. 2012 Jul 3;20(7):1135-40. Epub 2012 May 24. PMID:22632831 doi:10.1016/j.str.2012.04.004

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5z2q"

@@ Line 1: / Line 1: @@
 ==Vgll1-TEAD4 core complex==
-<StructureSection load='5z2q' size='340' side='right' caption='[[5z2q]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
+<StructureSection load='5z2q' size='340' side='right'caption='[[5z2q]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5z2q]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4eaz 4eaz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z2Q FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5z2q]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4eaz 4eaz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z2Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5Z2Q FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z2q OCA], [http://pdbe.org/5z2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z2q RCSB], [http://www.ebi.ac.uk/pdbsum/5z2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z2q ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5z2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z2q OCA], [http://pdbe.org/5z2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z2q RCSB], [http://www.ebi.ac.uk/pdbsum/5z2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z2q ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 22: / Line 22: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Pobbati, A V]]
 [[Category: Song, H]]

5z2q

From Proteopedia

Revision as of 21:13, 28 October 2020

Vgll1-TEAD4 core complex

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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