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1cxk

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[[Image:1cxk.gif|left|200px]]
[[Image:1cxk.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1cxk |SIZE=350|CAPTION= <scene name='initialview01'>1cxk</scene>, resolution 2.090&Aring;
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The line below this paragraph, containing "STRUCTURE_1cxk", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclomaltodextrin_glucanotransferase Cyclomaltodextrin glucanotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.19 2.4.1.19] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1cxk| PDB=1cxk | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cxk OCA], [http://www.ebi.ac.uk/pdbsum/1cxk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cxk RCSB]</span>
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}}
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'''COMPLEX BETWEEN A MALTONONAOSE SUBSTRATE AND BACILLUS CIRCULANS STRAIN 251 CGTASE E257Q/D229N'''
'''COMPLEX BETWEEN A MALTONONAOSE SUBSTRATE AND BACILLUS CIRCULANS STRAIN 251 CGTASE E257Q/D229N'''
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[[Category: Kalk, K H.]]
[[Category: Kalk, K H.]]
[[Category: Uitdehaag, J C.M.]]
[[Category: Uitdehaag, J C.M.]]
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[[Category: alpha-amylase family]]
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[[Category: Alpha-amylase family]]
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[[Category: glycosyl hydrolase family 13]]
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[[Category: Glycosyl hydrolase family 13]]
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[[Category: maltononaose]]
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[[Category: Maltononaose]]
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[[Category: substrate complex]]
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[[Category: Substrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:13:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:30:31 2008''
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Revision as of 10:13, 2 May 2008

Image:1cxk.gif

Template:STRUCTURE 1cxk

COMPLEX BETWEEN A MALTONONAOSE SUBSTRATE AND BACILLUS CIRCULANS STRAIN 251 CGTASE E257Q/D229N


Overview

Cyclodextrin glycosyltransferase (CGTase) is an enzyme of the alpha-amylase family, which uses a double displacement mechanism to process alpha-linked glucose polymers. We have determined two X-ray structures of CGTase complexes, one with an intact substrate at 2.1 A resolution, and the other with a covalently bound reaction intermediate at 1.8 A resolution. These structures give evidence for substrate distortion and the covalent character of the intermediate and for the first time show, in atomic detail, how catalysis in the alpha-amylase family proceeds by the concerted action of all active site residues.

About this Structure

1CXK is a Single protein structure of sequence from Bacillus circulans. Full crystallographic information is available from OCA.

Reference

X-ray structures along the reaction pathway of cyclodextrin glycosyltransferase elucidate catalysis in the alpha-amylase family., Uitdehaag JC, Mosi R, Kalk KH, van der Veen BA, Dijkhuizen L, Withers SG, Dijkstra BW, Nat Struct Biol. 1999 May;6(5):432-6. PMID:10331869 Page seeded by OCA on Fri May 2 13:13:14 2008

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