5h5z
From Proteopedia
(Difference between revisions)
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<StructureSection load='5h5z' size='340' side='right'caption='[[5h5z]], [[Resolution|resolution]] 1.74Å' scene=''> | <StructureSection load='5h5z' size='340' side='right'caption='[[5h5z]], [[Resolution|resolution]] 1.74Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5h5z]] is a 3 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5cnz 5cnz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H5Z OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5H5Z FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5h5z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Cteid Cteid]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5cnz 5cnz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H5Z OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5H5Z FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5h5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h5z OCA], [http://pdbe.org/5h5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h5z RCSB], [http://www.ebi.ac.uk/pdbsum/5h5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h5z ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UAA106 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7959 CTEID]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7959 CTEID])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5h5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h5z OCA], [http://pdbe.org/5h5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h5z RCSB], [http://www.ebi.ac.uk/pdbsum/5h5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h5z ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/Q6L7B0_CTEID Q6L7B0_CTEID]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.[SAAS:SAAS00359208] | [[http://www.uniprot.org/uniprot/Q6L7B0_CTEID Q6L7B0_CTEID]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.[SAAS:SAAS00359208] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Contemporary antigen presentation knowledge is based on the existence of a single beta2m locus, and a classical MHC class I forms a complex with a peptide (i.e., pMHC-I) to trigger CTL immunity. However, two beta2m loci have been found in diploid bony fish; the function of the two beta2m molecules is unclear. Here, we determined the variant peptide profiles originating from different products of the beta2m loci binding to the same MHC-I molecule and further solved the crystal structures of the two pMHC-I molecules (i.e., pCtid-UAA-beta2m-2 and pCtid-UAA-beta2m-1-II). Of note, in pCtid-UAA-beta2m-2, a unique hydrogen bond network formed in the bottom of the peptide-binding groove (PBG) led to alpha2-helix drift, ultimately leading to structural changes in the PBG. The mechanism of the change in peptide presentation profiles by beta2m molecules is illustrated. The results are also of great significance for antivirus and antitumor functions in cold-blooded vertebrates and even humans. | ||
| + | |||
| + | The Mechanism of beta2m Molecule-Induced Changes in the Peptide Presentation Profile in a Bony Fish.,Li Z, Zhang N, Ma L, Zhang L, Meng G, Xia C iScience. 2020 May 22;23(5):101119. doi: 10.1016/j.isci.2020.101119. Epub 2020, Apr 30. PMID:32438322<ref>PMID:32438322</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5h5z" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Cteid]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chen, R]] | [[Category: Chen, R]] | ||
Revision as of 07:28, 4 November 2020
Crystal structure of bony fish MHC class I, peptide and B2m II
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