Spectrin

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{{#tree:id=OrganizedByTopic|openlevels=0|
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* Spectrin α1
+
* Spectrin α1; Domains – N-terminal tetramerization 1-156; SH3 969-1025; C-terminal tetramerization 1902-2084
-
**[[3lbx]] – hSPTA1+hSPTB1 – human<br />
+
**[[3lbx]] – hSPT a chain N-terminal tetramerization domain +hSPT b chain C-terminal tetramerization domain – human<br />
-
**[[3i9q]], [[2rot]], [[2oaw]], [[2nuz]], [[1u06]] - cSPTA1 SH3 domain – chicken<br />
+
**[[2rot]], [[2oaw]], [[2nuz]], [[1u06]] - cSPT a chain SH3 domain – chicken<br />
-
**[[2jm8]], [[2jm9]], [[2cdt]], [[2f2v]], [[2f2w]], [[2f2x]] - cSPTA1 SH3 domain (mutant)<br />
+
**[[2jm8]], [[2jm9]], [[2cdt]], [[2f2v]], [[2f2w]], [[2f2x]], [[3i9q]] - cSPT a chain SH3 domain (mutant)<br />
-
**[[2jma]], [[2jmc]] - cSPTA1 SH3 domain (mutant)+P41 peptide<br />
+
**[[2rmo]], [[1neg]], [[1m8m]] - cSPT a chain SH3 domain – NMR<br />
-
**[[2rmo]], [[1neg]], [[1m8m]] - cSPTA1 SH3 domain – NMR
+
**[[2jma]], [[2jmc]] - cSPT a chain SH3 domain (mutant)+P41 peptide<br />
* Spectrin α2
* Spectrin α2
-
**[[3f31]] – hSPTA2 tetramerization domain<br />
+
**[[3f31]] – hSPT a2 chain N-terminal tetramerization domain<br />
-
**[[5fw9]], [[5fwb]], [[5fwc]], [[5ihi]], [[5ihk]], [[5ihn]] – hSPTA2 SH3 domain (mutant)<br />
+
**[[3fb2]] – hSPT a2 chain repeats 15-16 1337-1544<br />
-
**[[1qkw]] – cSPTA2 SH3 domain (mutant)<br />
+
**[[5fw9]], [[5fwb]], [[5fwc]], [[5ihi]], [[5ihk]], [[5ihn]] – hSPT a2 chain SH3 domain (mutant)<br />
-
**[[2fot]] - SPTA2+calmodulin – bovine<br />
+
**[[2fot]] - SPT a2 chain calmodulin-binding domain 1172-1211 +calmodulin – bovine<br />
-
**[[3fb2]] – hSPTA2 repeats 15-16<br />
+
**[[3thk]] - SPT a2 chain SH3 domain + polypeptide - rat
-
**[[3thk]] - SPTA2 SH3 domain + polypeptide - rat
+
**[[1qkw]] – cSPT a2 chain SH3 domain (mutant)<br />
* Spectrin α
* Spectrin α
-
**[[2kr3]], [[4f17]], [[4f16]] - cSPTA SH3 domain<br />
+
**[[1owa]] - hSPT a chain N-terminal tetramerization domain – NMR<br />
-
**[[1e6g]], [[1e6h]], [[1hd3]], [[1qkx]], [[1pwt]], [[1bk2]], [[1shg]], [[1h8k]], [[3ngp]], [[3m0p]], [[3m0q]], [[3m0r]], [[3m0s]], [[3m0t]], [[3m0u]] - cSPTA SH3 domain (mutant)<br />
+
**[[5j4o]] - hSPT a chain repeats 16-17 1599-1826<br />
-
**[[1uue]], [[1e7o]], [[1g2b]], [[1aey]], [[1tuc]], [[1tud]] - cSPTA SH3 domain (mutant) – NMR<br />
+
**[[2kr3]], [[4f17]], [[4f16]] - cSPT a chain SH3 domain<br />
-
**[[2lj3]] - cSPTA SH3 domain – NMR<br />
+
**[[1e6g]], [[1e6h]], [[1hd3]], [[1qkx]], [[1pwt]], [[1bk2]], [[1shg]], [[1h8k]], [[3ngp]], [[3m0p]], [[3m0q]], [[3m0r]], [[3m0s]], [[3m0t]], [[3m0u]] - cSPT a chain SH3 domain (mutant)<br />
-
**[[1u4q]] – cSPTA repeats 15-17 <br />
+
**[[1uue]], [[1e7o]], [[1g2b]], [[1aey]], [[1tuc]], [[1tud]] - cSPT a chain SH3 domain (mutant) – NMR<br />
-
**[[1u5p]] - cSPTA repeats 15-16<br />
+
**[[2lj3]] - cSPT a chain SH3 domain – NMR<br />
-
**[[1cun]] - cSPTA repeats 16-17<br />
+
**[[1u4q]] – cSPT a chain repeats 15-17 1662-1982<br />
-
**[[1aj3]] - cSPTA repeat 16 - NMR<br />
+
**[[1u5p]] - cSPT a chain repeats 15-16 1662-1876<br />
-
**[[1owa]] - hSPTA tetramerization domain – NMR<br />
+
**[[1cun]] - cSPT a chain repeats 16-17 (mutant) 1771-1982<br />
-
**[[5j4o]] - hSPTA repeats 16-17<br />
+
**[[1aj3]] - cSPT a chain repeat 16 1772-1869 - NMR<br />
* Spectrin β1
* Spectrin β1
-
**[[3bkt]], [[3kbu]] - hSPTB1+ankyrin<br />
+
**[[3kbt]], [[3kbu]] - hSPT β1 chain repeats 13-15 1583-1906 +ankyrin<br />
-
**[[3f57]], [[3edu]] - hSPTB1 ankyrin binding domain<br />
+
**[[3f57]], [[3edu]] - hSPT β1 chain repeats 14-15 1686-1906<br />
-
**[[1s35]] – hSPTB1 repeats 8-9
+
**[[1s35]] – hSPT β1 chain repeats 8-9 1063-1275 (mutant)
* Spectrin β2
* Spectrin β2
-
**[[3edv]] – hSPTB2 repeats 14-16
+
**[[3edv]] – hSPT β2 chain repeats 14-16 1697-2015
* Spectrin β3
* Spectrin β3
-
**[[1wyq]] – hSPTB3 CH domain – NMR<br />
+
**[[1wyq]] – hSPT β3 chain 2nd CH domain – NMR<br />
-
**[[1wjm]] – hSPTB3 – NMR<br />
+
**[[1wjm]] – hSPT β3 chain PH domain 2199-2328 – NMR<br />
-
**[[6anu]] - hSPTB3 ankyrin binding domain + actin - Cryo EM<br />
+
**[[6anu]] - hSPT β3 chain actin binding domain 1-284 + actin - Cryo EM<br />
* Spectrin β
* Spectrin β
-
**[[1bkr]], [[1aa2]] – hSPTB CH domain<br />
+
**[[1bkr]], [[1aa2]] – hSPT β chain 2nd CH domain 178-291<br />
-
**[[1mph]] – SPTB Pleckstrin Homology domain – NMR<br />
+
**[[1dro]], [[1mph]] - mSPT β chain PH domain 2199-2304 – NMR – mouse<br />
-
**[[1dro]] - mSPTB PH domain – NMR – mouse<br />
+
**[[1btn]] – mSPT β chain PH domain +inositol phosphate<br />
-
**[[1btn]] – mSPTB+inositol phosphate<br />
+
**[[2spc]] – SPT fragment 1391-1497 - ''Drosophila melanogaster''
-
**[[2spc]] – SPT fragment - ''Drosophila melanogaster''
+
* Spectrin R16
* Spectrin R16

Revision as of 11:19, 5 November 2020

Human spectrin α (grey) and β1 chain (green) 3lbx

Drag the structure with the mouse to rotate

3D Structures of Spectrin

Updated on 05-November-2020

References

  1. ↑ Das A, Base C, Dhulipala S, Dubreuil RR. Spectrin functions upstream of ankyrin in a spectrin cytoskeleton assembly pathway. J Cell Biol. 2006 Oct 23;175(2):325-35. PMID:17060500 doi:http://dx.doi.org/10.1083/jcb.200602095
  2. ↑ Coetzer T, Palek J, Lawler J, Liu SC, Jarolim P, Lahav M, Prchal JT, Wang W, Alter BP, Schewitz G, et al.. Structural and functional heterogeneity of alpha spectrin mutations involving the spectrin heterodimer self-association site: relationships to hematologic expression of homozygous hereditary elliptocytosis and hereditary pyropoikilocytosis. Blood. 1990 Jun 1;75(11):2235-44. PMID:2346784
  3. ↑ Dhermy D, Galand C, Bournier O, Cynober T, Mechinaud F, Tchemia G, Garbarz M. Hereditary spherocytosis with spectrin deficiency related to null mutations of the beta-spectrin gene. Blood Cells Mol Dis. 1998 Jun;24(2):251-61. PMID:9714702 doi:http://dx.doi.org/10.1006/bcmd.1998.0190

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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