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Stimulator of interferon genes

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**[[4loh]], [[4loi]] – hSTING CTD + c-di-GMP derivative<br />
**[[4loh]], [[4loi]] – hSTING CTD + c-di-GMP derivative<br />
**[[4qxo]], [[4qxp]], [[4qxq]], [[4qxr]] – hSTING CTD + chemptherapeutic agent DMXAA<br />
**[[4qxo]], [[4qxp]], [[4qxq]], [[4qxr]] – hSTING CTD + chemptherapeutic agent DMXAA<br />
 +
**[[6a06]] – pSTING CTD + cGAMP - pig<br />
 +
**[[6a05]] – pSTING CTD + purine derivative<br />
 +
**[[6a04]] – pSTING CTD + c-di-GMP<br />
 +
**[[6a03]], [[6iyf]] – pSTING CTD + c-di-AMP<br />
**[[5jej]] – hSTING residues 342-379 + IRF-3 <br />
**[[5jej]] – hSTING residues 342-379 + IRF-3 <br />
**[[4kby]] – mSTING CTD + c-di-GMP <br />
**[[4kby]] – mSTING CTD + c-di-GMP <br />

Revision as of 09:31, 9 November 2020

Structure of human STING CTD complex with c-GMP-AMP (PDB entry 4loh)

Drag the structure with the mouse to rotate

3D structures of STING

(Updated on 09-November-2020

References

  1. ↑ Poltorak A, Kurmyshkina O, Volkova T. Stimulator of interferon genes (STING): A "new chapter" in virus-associated cancer research. Lessons from wild-derived mouse models of innate immunity. Cytokine Growth Factor Rev. 2016 Jun;29:83-91. doi:, 10.1016/j.cytogfr.2016.02.009. Epub 2016 Mar 4. PMID:26980676 doi:http://dx.doi.org/10.1016/j.cytogfr.2016.02.009
  2. ↑ Gao P, Ascano M, Zillinger T, Wang W, Dai P, Serganov AA, Gaffney BL, Shuman S, Jones RA, Deng L, Hartmann G, Barchet W, Tuschl T, Patel DJ. Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA. Cell. 2013 Aug 15;154(4):748-62. doi: 10.1016/j.cell.2013.07.023. Epub 2013 Aug, 1. PMID:23910378 doi:10.1016/j.cell.2013.07.023

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