6er1

Structural highlights

Function

[CP190_DROME] Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may directly bind to insulator DNA at sites distinct from those recognized by su(Hw). Required during embryogenesis for axial expansion, an actin/myosin dependent process that distributes the dividing nuclei along the anterior-posterior axis of the syncytial embryo. Does not appear to play a crucial role in organizing centrosomal microtubules during mitosis.^{[1] [2] [3]}

References

1. ↑ Butcher RD, Chodagam S, Basto R, Wakefield JG, Henderson DS, Raff JW, Whitfield WG. The Drosophila centrosome-associated protein CP190 is essential for viability but not for cell division. J Cell Sci. 2004 Mar 1;117(Pt 7):1191-9. PMID:14996941 doi:http://dx.doi.org/10.1242/jcs.00979
2. ↑ Pai CY, Lei EP, Ghosh D, Corces VG. The centrosomal protein CP190 is a component of the gypsy chromatin insulator. Mol Cell. 2004 Dec 3;16(5):737-48. PMID:15574329 doi:http://dx.doi.org/S1097276504006732
3. ↑ Chodagam S, Royou A, Whitfield W, Karess R, Raff JW. The centrosomal protein CP190 regulates myosin function during early Drosophila development. Curr Biol. 2005 Jul 26;15(14):1308-13. PMID:16051175 doi:http://dx.doi.org/S0960-9822(05)00659-7