Squalene synthase
From Proteopedia
(Difference between revisions)
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**[[3wei]], [[3wej]], [[3wek]] – hSQS (mutant) + presqualene pyrophosphate <br /> | **[[3wei]], [[3wej]], [[3wek]] – hSQS (mutant) + presqualene pyrophosphate <br /> | ||
**[[3wca]], [[3wcb]], [[3wcc]], [[3wce]], [[3wcg]] – SQS (mutant) + FPP analog – ''Trypanosoma cruzi''<br /> | **[[3wca]], [[3wcb]], [[3wcc]], [[3wce]], [[3wcg]] – SQS (mutant) + FPP analog – ''Trypanosoma cruzi''<br /> | ||
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| + | *Dehydrosqualene synthase (DSQS) | ||
| + | |||
| + | **[[3vjd]], [[2zco]] – SaDSQS – ''Staphylococcus aureus'' <br /> | ||
| + | **[[3nri]] – SaDSQS + dehydrosqualene <br /> | ||
| + | **[[3npr]], [[3adz]] – SaSQS + presqualene pyrophosphate <br /> | ||
| + | **[[3lgz]] – SaSQS (mutant) + presqualene pyrophosphate <br /> | ||
| + | **[[3vje]] – SaDSQS (mutant) + zaragozic acid <br /> | ||
| + | **[[3ae0]] – SaDSQS + geranylgeranyl + thiopyrophosphate <br /> | ||
| + | **[[3w7f]], [[5yis]] – SaDSQS + farnesyl + thiopyrophosphate <br /> | ||
| + | **[[3acw]], [[3acx]], [[3acy]], [[3tfv]], [[3tfn]], [[3tfp]], [[4f6v]], [[4f6x]], [[2zcs]], [[2zcq]], [[2zy1]], [[2zcr]], [[4e9z]], [[4e9u]], [[4ea0]], [[4ea1]], [[4ea2]] – SaDSQS + inhibitor<br /> | ||
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Revision as of 10:32, 11 November 2020
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3D structures of squalene synthase
Updated on 11-November-2020
References
- ↑ Tansey TR, Shechter I. Squalene synthase: structure and regulation. Prog Nucleic Acid Res Mol Biol. 2001;65:157-95. PMID:11008488
- ↑ Kourounakis AP, Katselou MG, Matralis AN, Ladopoulou EM, Bavavea E. Squalene synthase inhibitors: An update on the search for new antihyperlipidemic and antiatherosclerotic agents. Curr Med Chem. 2011;18(29):4418-39. PMID:21864285
- ↑ Shang N, Li Q, Ko TP, Chan HC, Li J, Zheng Y, Huang CH, Ren F, Chen CC, Zhu Z, Galizzi M, Li ZH, Rodrigues-Poveda CA, Gonzalez-Pacanowska D, Veiga-Santos P, de Carvalho TM, de Souza W, Urbina JA, Wang AH, Docampo R, Li K, Liu YL, Oldfield E, Guo RT. Squalene synthase as a target for Chagas disease therapeutics. PLoS Pathog. 2014 May 1;10(5):e1004114. doi: 10.1371/journal.ppat.1004114., eCollection 2014 May. PMID:24789335 doi:http://dx.doi.org/10.1371/journal.ppat.1004114
