Stimulator of interferon genes
From Proteopedia
(Difference between revisions)
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*Stimulator of interferon genes | *Stimulator of interferon genes | ||
| - | **[[4ef5]], [[4f5w]], [[4f9e]] – hSTING CTD | + | Domain: CTD 139-379 |
| + | |||
| + | **[[6nt5]] – hSTING – human - Cryo EM <br /> | ||
| + | **[[4ef5]], [[4f5w]], [[4f9e]] – hSTING CTD<br /> | ||
**[[4f5e]] – hSTING CTD (mutant) <br /> | **[[4f5e]] – hSTING CTD (mutant) <br /> | ||
**[[4jc5]], [[4kc0]] – mSTING CTD - mouse <br /> | **[[4jc5]], [[4kc0]] – mSTING CTD - mouse <br /> | ||
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*Stimulator of interferon genes complex with ligand | *Stimulator of interferon genes complex with ligand | ||
| - | **[[4ef4]], [[4f5y]], [[4f9g]] | + | **[[4ef4]], [[4f5y]], [[4f9g]], [[4emt]] – hSTING CTD + c-di-GMP <br /> |
| - | + | ||
**[[4f5d]] – hSTING CTD (mutant) + c-di-GMP <br /> | **[[4f5d]] – hSTING CTD (mutant) + c-di-GMP <br /> | ||
| - | **[[4ksy]] – hSTING CTD + | + | **[[4ksy]] – hSTING CTD + c-GAMP <br /> |
**[[5bqx]] – hSTING CTD + c-GMP <br /> | **[[5bqx]] – hSTING CTD + c-GMP <br /> | ||
**[[4loh]], [[4loi]] – hSTING CTD + c-di-GMP derivative<br /> | **[[4loh]], [[4loi]] – hSTING CTD + c-di-GMP derivative<br /> | ||
| + | **[[6cff]] – hSTING CTD + c-di-AMP <br /> | ||
| + | **[[6dnk]] – hSTING CTD + c-GMP-AMP <br /> | ||
**[[4qxo]], [[4qxp]], [[4qxq]], [[4qxr]] – hSTING CTD + chemptherapeutic agent DMXAA<br /> | **[[4qxo]], [[4qxp]], [[4qxq]], [[4qxr]] – hSTING CTD + chemptherapeutic agent DMXAA<br /> | ||
| - | **[[6a06]] – pSTING CTD + | + | **[[6dxl]], [[6dxg]] – hSTING CTD (mutant) + imidazole derivative <br /> |
| + | **[[6a06]] – pSTING CTD + c-GAMP - pig<br /> | ||
**[[6a05]] – pSTING CTD + purine derivative<br /> | **[[6a05]] – pSTING CTD + purine derivative<br /> | ||
**[[6a04]] – pSTING CTD + c-di-GMP<br /> | **[[6a04]] – pSTING CTD + c-di-GMP<br /> | ||
Revision as of 08:16, 12 November 2020
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3D structures of STING
(Updated on 12-November-2020
Domain: CTD 139-379
References
- ↑ Poltorak A, Kurmyshkina O, Volkova T. Stimulator of interferon genes (STING): A "new chapter" in virus-associated cancer research. Lessons from wild-derived mouse models of innate immunity. Cytokine Growth Factor Rev. 2016 Jun;29:83-91. doi:, 10.1016/j.cytogfr.2016.02.009. Epub 2016 Mar 4. PMID:26980676 doi:http://dx.doi.org/10.1016/j.cytogfr.2016.02.009
- ↑ Gao P, Ascano M, Zillinger T, Wang W, Dai P, Serganov AA, Gaffney BL, Shuman S, Jones RA, Deng L, Hartmann G, Barchet W, Tuschl T, Patel DJ. Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA. Cell. 2013 Aug 15;154(4):748-62. doi: 10.1016/j.cell.2013.07.023. Epub 2013 Aug, 1. PMID:23910378 doi:10.1016/j.cell.2013.07.023
