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Sandbox GGC6
From Proteopedia
(Difference between revisions)
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| - | == | + | ==Fibrinogen alpha chain== |
<StructureSection load='3VEV' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='3VEV' size='340' side='right' caption='Caption for this structure' scene=''> | ||
This is a default text for your page '''Sandbox GGC6'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page '''Sandbox GGC6'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
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== Function == | == Function == | ||
| + | protease thrombin cleaves fibrinogen into monomers. The formation of monomers, fibrinogen beta, and fibrinogen alpha is insoluble fibrin matrix. fibrin works as a binding or trapping agent in the coagulation process, which creates blood clot. | ||
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| + | For small wounds, the polymerized fibrin with platelets forms a hemostatic plug over the wounds site. Fibrin is also anti inflammatory which it protects against IFNG- mediated hemorrhage. | ||
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| + | Afibrinogenemic pregnant patients will result in spontaneous miscarriage. Fibrinogen supplemental will allow the patients to sustain the pregnancy, therefore, maternal fibrinogen plays a important role for successful pregnancy. | ||
== Disease == | == Disease == | ||
Revision as of 18:04, 13 November 2020
Fibrinogen alpha chain
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
