Sandbox GGC1

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You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Function

histone H3 replaces H3 in a range of nucleosomes in active genes and it takes over the original H3 in non dividing cells. Nucleosomes wrap around and compact DNA into chromatin which limits DNA access to cellular machineries which need DNA as a template. Histones play an important role in regulation of transcription, DNA repair, DNA replication and also chromosomal stability. Access to DNA is regulated by post-translational modifications of histones which is called a histone code, and nucleosome remodeling. It also serves as a replacement histone that's imbedded chromatin regions by the HIRA chaperone, after the depletion of the H3.1 during transcription and DNA repair.

Disease

There have been studies that have identified mutations encoding a K27M substitution and there have also been mutations that encoded GLY 34 to ARG or VAL called the G34R/V substitution. There are mutations in H3.3 that are found in different types of bone tumors like chrondroblastoma for example and giant cell tumors of the bone. Chondroblastoma arises in children and in young adults in the cartilage of the growth plates of the long bones and is most typically benign.

Relevance

Histone octamer containing two of H2A, H2B, H3 and H4 and the octamer wraps 147bp of DNA. H3.3 interacts with HIRA which is a chaperone and ZMYND11 when trimethylated at

Structural highlights

in a PubMed abstract,CENP-Awhich is a centromere-specific histone H3 variant is over expressed in cancer cells and it can be mislocalized ectopically in the form of heterotypic nucleosomes containing H3.3.