Sandbox GGC3
From Proteopedia
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==Spike glycoprotein== | ==Spike glycoprotein== | ||
<StructureSection load='6VSB' size='340' side='right' caption='3D representation of the Spike glycoprotein' scene=''> | <StructureSection load='6VSB' size='340' side='right' caption='3D representation of the Spike glycoprotein' scene=''> | ||
| - | 3D structure representation of the Spike glycoprotein<ref>DOI 10.1002/ijch.201300024</ref> <ref>PMID:21638687</ref>. | + | 3D structure representation of the Spike glycoprotein related to the SARS-CoV-2 <ref>DOI 10.1002/ijch.201300024</ref> <ref>PMID:21638687</ref>. |
==Introduction== | ==Introduction== | ||
| - | The Spike protein is related to the novel coronavirus pandemic discovered in 2019. The virus is named as the severe acute respiratory syndrome coronavirus 2 (SARS- | + | The Spike protein is related to the novel coronavirus pandemic discovered in 2019. The virus is named as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and it belongs to the β coronavirus family. The SARS-CoV-2 is a single stranded RNA with 29,881bp length, which encodes for 9860 amino acids. It is compose of two proteins: the structural and non-structural proteins. The structural proteins are S,E,M and N ; whiles as the non-structural proteins are encoded on the ORF regions<ref>Huang, Y., Yang, C., Xu, X., Xu, W., & Liu, S. (2020). Structural and functional properties of SARS-CoV-2 spike protein: Potential antivirus drug development for COVID-19. Acta Pharmacologica Sinica, 41(9), 1141-1149. doi:10.1038/s41401-020-0485-4</ref>. |
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==The Spike Protein== | ==The Spike Protein== | ||
| - | The S-protein is a structural protein extends from the viral membrane and it is uniformly arranged as a trimer on the surface to give the crown-like appearance of the SARS- | + | The S-protein is a structural protein extends from the viral membrane and it is uniformly arranged as a trimer on the surface to give the crown-like appearance of the SARS-Co |
| + | V-2. The Spike protein is 14-1255bp long, which mediates a receptor binding and fusion of the virus and a cellular membrane. Is also gives the virus its name in Latin as "Corona". | ||
==Domains== | ==Domains== | ||
| - | The S-protein of the SARS- | + | The S-protein of the SARS-CoV-2 has two main subunits , an S1 and S2 subunits. The S1 subunit is located on residue #14–685 ( contains the NTD) and interact with human AEC2 by attaching its virion to the cell membrane by interacting with host receptor. The S2 subunit is located on residue #686–1273 ( contains the CT) which serves as the fusion protein of the virus. |
==Activation of S-protein== | ==Activation of S-protein== | ||
Revision as of 04:45, 16 November 2020
Spike glycoprotein
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Huang, Y., Yang, C., Xu, X., Xu, W., & Liu, S. (2020). Structural and functional properties of SARS-CoV-2 spike protein: Potential antivirus drug development for COVID-19. Acta Pharmacologica Sinica, 41(9), 1141-1149. doi:10.1038/s41401-020-0485-4
