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1hwj

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==COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH CERIVASTATIN==
==COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH CERIVASTATIN==
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<StructureSection load='1hwj' size='340' side='right' caption='[[1hwj]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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<StructureSection load='1hwj' size='340' side='right'caption='[[1hwj]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1hwj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HWJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1hwj]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HWJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1HWJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=116:7-[4-(4-FLUORO-PHENYL)-5-HYDROXYMETHYL-2,6-DIISOPROPYL-PYRIDIN-3-YL]-3,5-DIHYDROXY-HEPTANOIC+ACID'>116</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=116:7-[4-(4-FLUORO-PHENYL)-5-HYDROXYMETHYL-2,6-DIISOPROPYL-PYRIDIN-3-YL]-3,5-DIHYDROXY-HEPTANOIC+ACID'>116</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dq8|1dq8]], [[1dq9|1dq9]], [[1dqa|1dqa]], [[1hw8|1hw8]], [[1hw9|1hw9]], [[1hwi|1hwi]], [[1hwk|1hwk]], [[1hwl|1hwl]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dq8|1dq8]], [[1dq9|1dq9]], [[1dqa|1dqa]], [[1hw8|1hw8]], [[1hw9|1hw9]], [[1hwi|1hwi]], [[1hwk|1hwk]], [[1hwl|1hwl]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HMGCR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HMGCR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_reductase_(NADPH) Hydroxymethylglutaryl-CoA reductase (NADPH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.34 1.1.1.34] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_reductase_(NADPH) Hydroxymethylglutaryl-CoA reductase (NADPH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.34 1.1.1.34] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hwj OCA], [http://pdbe.org/1hwj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hwj RCSB], [http://www.ebi.ac.uk/pdbsum/1hwj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hwj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1hwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hwj OCA], [http://pdbe.org/1hwj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hwj RCSB], [http://www.ebi.ac.uk/pdbsum/1hwj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hwj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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</div>
</div>
<div class="pdbe-citations 1hwj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1hwj" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[HMG-CoA Reductase|HMG-CoA Reductase]]
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*[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Deisenhofer, J]]
[[Category: Deisenhofer, J]]
[[Category: Istvan, E S]]
[[Category: Istvan, E S]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]

Revision as of 10:34, 18 November 2020

COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH CERIVASTATIN

PDB ID 1hwj

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