1i05

From Proteopedia

(Difference between revisions)

Revision as of 10:34, 18 November 2020

CRYSTAL STRUCTURE OF MOUSE MAJOR URINARY PROTEIN (MUP-I) COMPLEXED WITH HYDROXY-METHYL-HEPTANONE

Structural highlights

1i05 is a 1 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	1mup, 1io4, 1io6
Gene:	MUP-I (LK3 transgenic mice)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[MUP6_MOUSE] Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The mouse major urinary proteins are pheromone-binding proteins that function as carriers of volatile effectors of mouse physiology and behavior. Crystal structures of recombinant mouse major urinary protein-I (MUP-I) complexed with the synthetic pheromones, 2-sec-butyl-4,5-dihydrothiazole and 6-hydroxy-6-methyl-3-heptanone, have been determined at high resolution. The purification of MUP-I from mouse liver and a high-resolution structure of the natural isolate are also reported. These results show the binding of 6-hydroxy-6-methyl-3-heptanone to MUP-I, unambiguously define ligand orientations for two pheromones within the MUP-I binding site, and suggest how different chemical classes of pheromones can be accommodated within the MUP-I beta-barrel.

Structural basis of pheromone binding to mouse major urinary protein (MUP-I).,Timm DE, Baker LJ, Mueller H, Zidek L, Novotny MV Protein Sci. 2001 May;10(5):997-1004. PMID:11316880^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Timm DE, Baker LJ, Mueller H, Zidek L, Novotny MV. Structural basis of pheromone binding to mouse major urinary protein (MUP-I). Protein Sci. 2001 May;10(5):997-1004. PMID:11316880

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1i05"

@@ Line 1: / Line 1: @@
 ==CRYSTAL STRUCTURE OF MOUSE MAJOR URINARY PROTEIN (MUP-I) COMPLEXED WITH HYDROXY-METHYL-HEPTANONE==
-<StructureSection load='1i05' size='340' side='right' caption='[[1i05]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+<StructureSection load='1i05' size='340' side='right'caption='[[1i05]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1i05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1I05 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1i05]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I05 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1I05 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=LTL:6-HYDROXY-6-METHYL-HEPTAN-3-ONE'>LTL</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=LTL:6-HYDROXY-6-METHYL-HEPTAN-3-ONE'>LTL</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mup|1mup]], [[1io4|1io4]], [[1io6|1io6]]</td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MUP-I ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i05 OCA], [http://pdbe.org/1i05 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i05 RCSB], [http://www.ebi.ac.uk/pdbsum/1i05 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1i05 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1i05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i05 OCA], [http://pdbe.org/1i05 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1i05 RCSB], [http://www.ebi.ac.uk/pdbsum/1i05 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1i05 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 34: / Line 34: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Lk3 transgenic mice]]
 [[Category: Baker, L J]]

1i05

From Proteopedia

Revision as of 10:34, 18 November 2020

CRYSTAL STRUCTURE OF MOUSE MAJOR URINARY PROTEIN (MUP-I) COMPLEXED WITH HYDROXY-METHYL-HEPTANONE

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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