1d3u

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[[Image:1d3u.gif|left|200px]]
[[Image:1d3u.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1d3u", creates the "Structure Box" on the page.
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{{STRUCTURE_1d3u| PDB=1d3u | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d3u OCA], [http://www.ebi.ac.uk/pdbsum/1d3u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d3u RCSB]</span>
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'''TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/BRE+TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI'''
'''TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/BRE+TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI'''
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[[Category: Littlefield, O.]]
[[Category: Littlefield, O.]]
[[Category: Sigler, P B.]]
[[Category: Sigler, P B.]]
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[[Category: hyperthermophile]]
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[[Category: Hyperthermophile]]
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[[Category: protein-dna complex]]
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[[Category: Protein-dna complex]]
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[[Category: transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:25:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:34:04 2008''
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Revision as of 10:25, 2 May 2008

Image:1d3u.gif

Template:STRUCTURE 1d3u

TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/BRE+TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI


Overview

Recently the definition of the metazoan RNA polymerase II and archaeal core promoters has been expanded to include a region immediately upstream of the TATA box called the B recognition element (BRE), so named because eukaryal transcription factor TFIIB and its archaeal orthologue TFB interact with the element in a sequence-specific manner. Here we present the 2.4-A crystal structure of archaeal TBP and the C-terminal core of TFB (TFB(c)) in a complex with an extended TATA-box-containing promoter that provides a detailed picture of the stereospecific interactions between the BRE and a helix-turn-helix motif in the C-terminal cyclin repeat of TFB(c). This interaction is important in determining the level of basal transcription and explicitly defines the direction of transcription.

About this Structure

1D3U is a Protein complex structure of sequences from Pyrococcus woesei. Full crystallographic information is available from OCA.

Reference

The structural basis for the oriented assembly of a TBP/TFB/promoter complex., Littlefield O, Korkhin Y, Sigler PB, Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13668-73. PMID:10570130 Page seeded by OCA on Fri May 2 13:25:18 2008

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