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Tetherin
From Proteopedia
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| - | '''Tetherin''' has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. | + | '''Tetherin''' or '''bone marrow stromal antigen 2''' (BST-2) has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles. |
The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells. The tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. | The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells. The tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine. | ||
Revision as of 09:21, 23 November 2020
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3D structures of tetherin
Updated on 23-November-2020
2x7a, 3nwh, 2xg7, 3mqb, 3mqc – hBST2 ectodomain – human
3mq7, 3mq9, 2lk9 - hBST2 ectodomain (mutant)
3ni0 - BST2 ectodomain – mouse
References
Sakuma, Noda, Urata, Kawaoka, & Yasuda (2009). Inhibition of Lassa and Marburg Virus Production by Tetherin. Journal of Virology. 83:2382-2385.
Neil, Zang, & Beiniasz (2008). Tetherin inhibits retroviral release and is antagonized by HIV-1 Vpu. Nature. 451: 425-430.
