Mycobacterium Tuberculosis Transpeptidase Domain

Tuberculosis (TB) is one of the major human respiratory diseases which is caused by Mycobacterium Tuberculosis. The infection of M. tuberculosis causes a large area of necrosis of pulmonary tissue, which results in significant breathing difficulties. TB is also known to be a major causing agent for chronic obstructive pulmonary disease (COPD). Nowadays, TB proposes a significant problem in antibiotic resistance, traditional antibiotics gradually become less and less effective towards the antibiotic-resistant strain of M. tuberculosis. In order to develop a novel antibiotic, further research has led us into the mechanism of how known antibiotic acts on M. tuberculosis. A new therapeutic approach is taken by investigating the penicillium binding site PonA1.

Function

Two types of penicillium binding proteins (PBPs) can be found in M. tuberculosis, which is PonA1 and PonA2. PonA1 is responsible for the integrity of the poly peptidoglycans, which also regulates the cell wall in the growth of the cell cycle. From research suggest that the function of PBPs PonA2 possess the ability to sense cell cycle and responsible for protein-carbohydrates interactions.

When the ß-lactams bind to the PBPs, it induces the degradation of the cell wall by inhibits the activity of transpeptidase.

Disease

TB is a human pulmonary disease which

Relevance

Structural highlights

Penicillin V binds to the transpeptidase domain of this protein. , penicillin V is shown as ball and stick, with the carbon atoms in red.