1dci

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1dci" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dci, resolution 1.5&Aring;" /> '''DIENOYL-COA ISOMERAS...)
Next diff →

Revision as of 15:51, 29 October 2007

Image:1dci.gif

1dci, resolution 1.5Å

Drag the structure with the mouse to rotate

DIENOYL-COA ISOMERASE

Overview

BACKGROUND: The degradation of unsaturated fatty acids is vital to all, living organisms. Certain unsaturated fatty acids must be catabolized via, a pathway auxiliary to the main beta-oxidation pathway. Dienoyl-coenzyme A, (dienoyl-CoA) isomerase catalyzes one step of this auxiliary pathway, the, isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, and is imported into both mitochondria and peroxisomes. Dienoyl-CoA, isomerase belongs to a family of CoA-binding proteins that share the, enoyl-CoA hydratase/isomerase sequence motif. RESULTS: The crystal, structure of rat dienoyl-CoA isomerase has been determined at 1.5 A, resolution. The fold closely resembles that of enoyl-CoA hydratase and, 4-chlorobenzoyl-CoA dehalogenase. Dienoyl-CoA isomerase forms hexamers, made ... [(full description)]

About this Structure

1DCI is a [Single protein] structure of sequence from [Rattus norvegicus] with SO4, MG and EDO as [ligands]. Active as [[1]], with EC number [4.2.1.17]. Full crystallographic information is available from [OCA].

Reference

The crystal structure of dienoyl-CoA isomerase at 1.5 A resolution reveals the importance of aspartate and glutamate sidechains for catalysis., Modis Y, Filppula SA, Novikov DK, Norledge B, Hiltunen JK, Wierenga RK, Structure. 1998 Aug 15;6(8):957-70. PMID:9739087

Page seeded by OCA on Mon Oct 29 17:56:32 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dci"
Personal tools