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6kyp
From Proteopedia
(Difference between revisions)
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| - | == | + | ==X-ray structure of human PPARalpha ligand binding domain-GW9662-clofibric acid co-crystals obtained by delipidation and co-crystallization== |
| - | <StructureSection load='6kyp' size='340' side='right'caption='[[6kyp]]' scene=''> | + | <StructureSection load='6kyp' size='340' side='right'caption='[[6kyp]], [[Resolution|resolution]] 2.86Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KYP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KYP FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6kyp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KYP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KYP FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kyp OCA], [http://pdbe.org/6kyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kyp RCSB], [http://www.ebi.ac.uk/pdbsum/6kyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kyp ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E0O:2-(4-chloranylphenoxy)-2-methyl-propanoic+acid'>E0O</scene>, <scene name='pdbligand=GW9:2-CHLORO-5-NITRO-N-PHENYLBENZAMIDE'>GW9</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kyp OCA], [http://pdbe.org/6kyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kyp RCSB], [http://www.ebi.ac.uk/pdbsum/6kyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kyp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN]] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Honda A]] | + | [[Category: Honda, A]] |
| - | [[Category: Ishii I]] | + | [[Category: Ishii, I]] |
| - | [[Category: Ishikawa R]] | + | [[Category: Ishikawa, R]] |
| - | [[Category: Kamata S]] | + | [[Category: Kamata, S]] |
| - | [[Category: Oyama T]] | + | [[Category: Oyama, T]] |
| - | [[Category: Saito K]] | + | [[Category: Saito, K]] |
| + | [[Category: Nuclear receptor]] | ||
| + | [[Category: Ppar]] | ||
| + | [[Category: Protein-ligand complex]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 07:05, 25 November 2020
X-ray structure of human PPARalpha ligand binding domain-GW9662-clofibric acid co-crystals obtained by delipidation and co-crystallization
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Categories: Human | Large Structures | Honda, A | Ishii, I | Ishikawa, R | Kamata, S | Oyama, T | Saito, K | Nuclear receptor | Ppar | Protein-ligand complex | Transcription
