1jss

From Proteopedia

(Difference between revisions)

Revision as of 07:35, 25 November 2020

Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4).

Structural highlights

1jss is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	BC005642; Unigene Cluster: Mm. 31508 (LK3 transgenic mice)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

[STAR4_MOUSE] May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The x-ray structure of the mouse cholesterol-regulated START protein 4 (StarD4) has been determined at 2.2-A resolution, revealing a compact alpha/beta structure related to the START domain present in the cytoplasmic C-terminal portion of human MLN64. The volume of the putative lipid-binding tunnel was estimated at 847 A(3), which is consistent with the binding of one cholesterol-size lipid molecule. Comparison of the tunnel-lining residues in StarD4 and MLN64-START permitted identification of possible lipid specificity determinants in both molecular tunnels. Homology modeling of related proteins, and comparison of the StarD4 and MLN64-START structures, showed that StarD4 is a member of a large START domain superfamily characterized by the helix-grip fold. Additional mechanistic and evolutionary studies should be facilitated by the availability of a second START domain structure from a distant relative of MLN64.

Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain.,Romanowski MJ, Soccio RE, Breslow JL, Burley SK Proc Natl Acad Sci U S A. 2002 May 14;99(10):6949-54. PMID:12011453^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Romanowski MJ, Soccio RE, Breslow JL, Burley SK. Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6949-54. PMID:12011453 doi:http://dx.doi.org/10.1073/pnas.052140699

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jss"

@@ Line 1: / Line 1: @@
 ==Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4).==
-<StructureSection load='1jss' size='340' side='right' caption='[[1jss]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+<StructureSection load='1jss' size='340' side='right'caption='[[1jss]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1jss]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JSS FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1jss]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1JSS FirstGlance]. <br>
 </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BC005642; Unigene Cluster: Mm. 31508 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jss OCA], [http://pdbe.org/1jss PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jss RCSB], [http://www.ebi.ac.uk/pdbsum/1jss PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jss ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/1jss TOPSAN]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1jss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jss OCA], [http://pdbe.org/1jss PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jss RCSB], [http://www.ebi.ac.uk/pdbsum/1jss PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jss ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/1jss TOPSAN]</span></td></tr>
 </table>
 == Function ==
@@ Line 32: / Line 32: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Lk3 transgenic mice]]
 [[Category: Breslow, J L]]

1jss

From Proteopedia

Revision as of 07:35, 25 November 2020

Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4).

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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