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1jya

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Revision as of 07:37, 25 November 2020

Crystal Structure of SycE

Structural highlights

1jya is a 2 chain structure with sequence from "bacillus_pseudotuberkulosis"_(sic)_pfeiffer_1889 "bacillus pseudotuberkulosis" (sic) pfeiffer 1889. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Gene:	syce ("Bacillus pseudotuberkulosis" (sic) Pfeiffer 1889)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[YERA_YERPE] Positive regulator of YopE.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

In the type III secretory system of bacterial pathogens, a large number of sequence-divergent but characteristically small (approximately 14-19 kDa), acidic (pI approximately 4-5) chaperone proteins have been identified. We present the 1.74 A resolution crystal structure of the Yersinia pseudotuberculosis chaperone SycE, whose action in promoting translocation of YopE into host macrophages is essential to Yersinia pathogenesis. SycE, a compact, globular dimer with a novel fold, has two large hydrophobic surface patches that may form binding sites for YopE or other type III components. These patches are formed by structurally key residues that are conserved among many chaperones, suggesting shared structural and functional relationships. A negative electrostatic potential covers almost the entire surface of SycE and is likely conserved in character, but not in detail, among chaperones. The structure provides the first structural insights into possible modes of action of SycE and type III chaperones in general.

Structure of the Yersinia type III secretory system chaperone SycE.,Birtalan S, Ghosh P Nat Struct Biol. 2001 Nov;8(11):974-8. PMID:11685245^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Birtalan S, Ghosh P. Structure of the Yersinia type III secretory system chaperone SycE. Nat Struct Biol. 2001 Nov;8(11):974-8. PMID:11685245 doi:10.1038/nsb1101-974

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jya"

@@ Line 1: / Line 1: @@
 ==Crystal Structure of SycE==
-<StructureSection load='1jya' size='340' side='right' caption='[[1jya]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
+<StructureSection load='1jya' size='340' side='right'caption='[[1jya]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1jya]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudotuberkulosis"_(sic)_pfeiffer_1889 "bacillus pseudotuberkulosis" (sic) pfeiffer 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYA FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1jya]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pseudotuberkulosis"_(sic)_pfeiffer_1889 "bacillus pseudotuberkulosis" (sic) pfeiffer 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1JYA FirstGlance]. <br>
 </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">syce ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=633 "Bacillus pseudotuberkulosis" (sic) Pfeiffer 1889])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jya OCA], [http://pdbe.org/1jya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jya RCSB], [http://www.ebi.ac.uk/pdbsum/1jya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jya ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1jya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jya OCA], [http://pdbe.org/1jya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jya RCSB], [http://www.ebi.ac.uk/pdbsum/1jya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jya ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 33: / Line 33: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Birtalan, S]]
 [[Category: Ghosh, P]]

1jya

From Proteopedia

Revision as of 07:37, 25 November 2020

Crystal Structure of SycE

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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