1d5s

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[[Image:1d5s.gif|left|200px]]
[[Image:1d5s.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1d5s| PDB=1d5s | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d5s OCA], [http://www.ebi.ac.uk/pdbsum/1d5s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d5s RCSB]</span>
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'''CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER'''
'''CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER'''
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[[Category: Rossjohn, J.]]
[[Category: Rossjohn, J.]]
[[Category: Whisstock, J C.]]
[[Category: Whisstock, J C.]]
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[[Category: a beta sheet polymerisation]]
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[[Category: A beta sheet polymerisation]]
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[[Category: rcl cleavage]]
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[[Category: Rcl cleavage]]
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[[Category: serpin fold]]
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[[Category: Serpin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:28:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:35:08 2008''
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Revision as of 10:28, 2 May 2008

Image:1d5s.gif

Template:STRUCTURE 1d5s

CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER


Overview

Alpha1-antitrypsin deficiency, which can lead to both emphysema and liver disease, is a result of the accumulation of alpha1-antitrypsin polymers within the hepatocyte. A wealth of biochemical and biophysical data suggests that alpha1-antitrypsin polymers form via insertion of residues from the reactive center loop of one molecule into the beta-sheet of another. However, this long-standing hypothesis has not been confirmed by direct structural evidence. Here, we describe the first crystallographic evidence of a beta-strand linked polymer form of alpha1-antitrypsin: the crystal structure of a cleaved alpha1-antitrypsin polymer.

About this Structure

1D5S is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Cleaved antitrypsin polymers at atomic resolution., Dunstone MA, Dai W, Whisstock JC, Rossjohn J, Pike RN, Feil SC, Le Bonniec BF, Parker MW, Bottomley SP, Protein Sci. 2000 Feb;9(2):417-20. PMID:10716194 Page seeded by OCA on Fri May 2 13:28:52 2008

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