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1d5t

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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d5t OCA], [http://www.ebi.ac.uk/pdbsum/1d5t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d5t RCSB]</span>
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'''GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM'''
'''GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM'''
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[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
[[Category: Zeng, K.]]
[[Category: Zeng, K.]]
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[[Category: ultra-high resolution]]
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[[Category: Ultra-high resolution]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:28:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:35:19 2008''
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Revision as of 10:28, 2 May 2008

Image:1d5t.jpg

Template:STRUCTURE 1d5t

GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM


Overview

Guanine nucleotide dissociation inhibitor (GDI) is a 55-kDa protein that functions in vesicular membrane transport to recycle Rab GTPases. We have now determined the crystal structure of bovine alpha-GDI at ultra-high resolution (1.04 A). Refinement at this resolution highlighted a region with high mobility of its main-chain residues. This corresponded to a surface loop in the primarily alpha-helical domain II at the base of alpha-GDI containing the previously uncharacterized sequence-conserved region (SCR) 3A. Site-directed mutagenesis showed that this mobile loop plays a crucial role in binding of GDI to membranes and extraction of membrane-bound Rab. This domain, referred to as the mobile effector loop, in combination with Rab-binding residues found in the multi-sheet domain I at the apex of alpha-GDI may provide flexibility for recycling of diverse Rab GTPases. We propose that conserved residues in domains I and II synergize to form the functional face of GDI, and that domain II mediates a critical step in Rab recycling during vesicle fusion.

About this Structure

1D5T is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

A new functional domain of guanine nucleotide dissociation inhibitor (alpha-GDI) involved in Rab recycling., Luan P, Heine A, Zeng K, Moyer B, Greasely SE, Kuhn P, Balch WE, Wilson IA, Traffic. 2000 Mar;1(3):270-81. PMID:11208110 Page seeded by OCA on Fri May 2 13:28:58 2008

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