TIR domain-containing adapter protein

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<StructureSection load='3ub2' size='340' side='right' caption='MAL adaptor protein TIR domain complex with dithiothreitol (PDB code [[3ub2]])' scene=''>
<StructureSection load='3ub2' size='340' side='right' caption='MAL adaptor protein TIR domain complex with dithiothreitol (PDB code [[3ub2]])' scene=''>
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'''TIR domain-containing adaptor protein''' or '''Toll/Interleukin-1 receptor domain-containing adaptor protein''' (TIRAP) is one of 5 proteins involved in the Toll interleukin 1 receptor signaling pathway of the immune system. The 5 adaptor proteins are: '''MyD88, MAL, TRIF, TRAM and SARM'''. The TIR domain, which is found in Toll-like receptors and in adaptor proteins. The domain containing 135 to 160 amino acids, consists of 3 boxes of conserved residues. The TIR domain is involved in the interaction between Toll-like receptors and the adaptor protein<ref>PMID:17457343</ref>. TIRAP activates NF-kB, MAPK1, MAPK3 and JNK which results in the inflammatory response.
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'''TIR domain-containing adapter protein''' or '''Toll/Interleukin-1 receptor domain-containing adapter protein''' (TIRAP) is one of 5 proteins involved in the Toll interleukin 1 receptor signaling pathway of the immune system. The 5 adaptor proteins are: '''MyD88, MAL, TRIF, TRAM and SARM'''. The TIR domain is found in Toll-like receptors and in adaptor proteins. The domain containing 135 to 160 amino acids, consists of 3 boxes of conserved residues. The TIR domain is involved in the interaction between Toll-like receptors and the adaptor protein<ref>PMID:17457343</ref>. TIRAP activates NF-kB, MAPK1, MAPK3 and JNK which results in the inflammatory response.
</StructureSection>
</StructureSection>
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== 3D Structures of TIR domain-containing adaptor protein ==
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== 3D Structures of TIR domain-containing adapter protein ==
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*MyD88
*MyD88
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**[[4fz5]], [[4lqd]], [[4dom]], [[4eo7]] – hMyD88 TIR domain <br />
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**[[4fz5]], [[4lqd]], [[4dom]], [[4eo7]] – hMyD88 TIR domain 157-296<br />
**[[2z5v]] – hMyD88 TIR domain - NMR<br />
**[[2z5v]] – hMyD88 TIR domain - NMR<br />
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**[[4c0m]] – hTRIF N-terminal domain <br />
**[[4c0m]] – hTRIF N-terminal domain <br />
**[[4bsx]] – hTRIF N-terminal domain (mutant)<br />
**[[4bsx]] – hTRIF N-terminal domain (mutant)<br />
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*TcpB
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**[[4lqc]], [[4c7m]] – TcpB TIR domain (mutant) – ''Brucella melitensis''<br />
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Revision as of 10:36, 30 November 2020

MAL adaptor protein TIR domain complex with dithiothreitol (PDB code 3ub2)

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3D Structures of TIR domain-containing adapter protein

Updated on 30-November-2020


References

  1. ↑ O'Neill LA, Bowie AG. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol. 2007 May;7(5):353-64. PMID:17457343 doi:http://dx.doi.org/nri2079

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Michal Harel, Alexander Berchansky, Jaime Prilusky

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