1d65

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[[Image:1d65.gif|left|200px]]
[[Image:1d65.gif|left|200px]]
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{{Structure
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|PDB= 1d65 |SIZE=350|CAPTION= <scene name='initialview01'>1d65</scene>, resolution 2.200&Aring;
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The line below this paragraph, containing "STRUCTURE_1d65", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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{{STRUCTURE_1d65| PDB=1d65 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d65 OCA], [http://www.ebi.ac.uk/pdbsum/1d65 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d65 RCSB]</span>
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'''MOLECULAR STRUCTURE OF THE B-DNA DODECAMER D(CGCAAATTTGCG)2; AN EXAMINATION OF PROPELLER TWIST AND MINOR-GROOVE WATER STRUCTURE AT 2.2 ANGSTROMS RESOLUTION'''
'''MOLECULAR STRUCTURE OF THE B-DNA DODECAMER D(CGCAAATTTGCG)2; AN EXAMINATION OF PROPELLER TWIST AND MINOR-GROOVE WATER STRUCTURE AT 2.2 ANGSTROMS RESOLUTION'''
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==About this Structure==
==About this Structure==
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1D65 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D65 OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D65 OCA].
==Reference==
==Reference==
Molecular structure of the B-DNA dodecamer d(CGCAAATTTGCG)2. An examination of propeller twist and minor-groove water structure at 2.2 A resolution., Edwards KJ, Brown DG, Spink N, Skelly JV, Neidle S, J Mol Biol. 1992 Aug 20;226(4):1161-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1518049 1518049]
Molecular structure of the B-DNA dodecamer d(CGCAAATTTGCG)2. An examination of propeller twist and minor-groove water structure at 2.2 A resolution., Edwards KJ, Brown DG, Spink N, Skelly JV, Neidle S, J Mol Biol. 1992 Aug 20;226(4):1161-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1518049 1518049]
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[[Category: Protein complex]]
 
[[Category: Brown, D G.]]
[[Category: Brown, D G.]]
[[Category: Edwards, K J.]]
[[Category: Edwards, K J.]]
[[Category: Neidle, S.]]
[[Category: Neidle, S.]]
[[Category: Spink, N.]]
[[Category: Spink, N.]]
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[[Category: b-dna]]
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[[Category: B-dna]]
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[[Category: double helix]]
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[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:29:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:35:23 2008''
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Revision as of 10:29, 2 May 2008

Image:1d65.gif

Template:STRUCTURE 1d65

MOLECULAR STRUCTURE OF THE B-DNA DODECAMER D(CGCAAATTTGCG)2; AN EXAMINATION OF PROPELLER TWIST AND MINOR-GROOVE WATER STRUCTURE AT 2.2 ANGSTROMS RESOLUTION


Overview

The crystal structure of the dodecanucleotide duplex d(CGCAAATTTGCG)2 has been solved to 2.2 A resolution and refined to an R-factor of 18.1% with the inclusion of 71 water molecules. The structure shows propeller twists of up to -20 degrees for the A.T base-pairs, although there is probably only one (weak) three-centre hydrogen bond in the six base-pair AT narrow minor-groove region. An extensive ribbon of hydration has been located in this groove that has features distinctive from the classic "spine of hydration". Solvation around phosphate groups is described, with several instances of water molecules bridging between phosphates.

About this Structure

Full crystallographic information is available from OCA.

Reference

Molecular structure of the B-DNA dodecamer d(CGCAAATTTGCG)2. An examination of propeller twist and minor-groove water structure at 2.2 A resolution., Edwards KJ, Brown DG, Spink N, Skelly JV, Neidle S, J Mol Biol. 1992 Aug 20;226(4):1161-73. PMID:1518049 Page seeded by OCA on Fri May 2 13:29:37 2008

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