6qdh
From Proteopedia
(Difference between revisions)
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==Leishmania major N-myristoyltransferase in complex with quinazoline inhibitor IMP-0000906== | ==Leishmania major N-myristoyltransferase in complex with quinazoline inhibitor IMP-0000906== | ||
| - | <StructureSection load='6qdh' size='340' side='right'caption='[[6qdh]]' scene=''> | + | <StructureSection load='6qdh' size='340' side='right'caption='[[6qdh]], [[Resolution|resolution]] 1.45Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QDH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6QDH FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6qdh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QDH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6QDH FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6qdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qdh OCA], [http://pdbe.org/6qdh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qdh RCSB], [http://www.ebi.ac.uk/pdbsum/6qdh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qdh ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HXQ:4-[ethyl(methyl)amino]-2-[methyl-(1-methylpiperidin-4-yl)amino]-~{N}-(1,3,5-trimethylpyrazol-4-yl)quinazoline-6-sulfonamide'>HXQ</scene>, <scene name='pdbligand=HZ5:~{N}-(1,3,5-trimethylpyrazol-4-yl)methanesulfonamide'>HZ5</scene>, <scene name='pdbligand=HZ8:~{N}4-ethyl-~{N}2,~{N}4-dimethyl-~{N}2-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine'>HZ8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4cgo|4cgo]]</div></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NMT, LMJF_32_0080 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 LEIMA])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6qdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qdh OCA], [http://pdbe.org/6qdh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qdh RCSB], [http://www.ebi.ac.uk/pdbsum/6qdh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qdh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Glycylpeptide N-tetradecanoyltransferase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Brannigan | + | [[Category: Leima]] |
| + | [[Category: Brannigan, J A]] | ||
| + | [[Category: Leishmania]] | ||
| + | [[Category: Myristoylation]] | ||
| + | [[Category: Quinazoline]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 08:06, 2 December 2020
Leishmania major N-myristoyltransferase in complex with quinazoline inhibitor IMP-0000906
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