6rlw
From Proteopedia
(Difference between revisions)
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==Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with inhibitor TH5487== | ==Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with inhibitor TH5487== | ||
| - | <StructureSection load='6rlw' size='340' side='right'caption='[[6rlw]]' scene=''> | + | <StructureSection load='6rlw' size='340' side='right'caption='[[6rlw]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RLW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RLW FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6rlw]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RLW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RLW FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rlw OCA], [http://pdbe.org/6rlw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rlw RCSB], [http://www.ebi.ac.uk/pdbsum/6rlw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rlw ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K8Q:4-(4-bromanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide'>K8Q</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OGG1, MMH, MUTM, OGH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rlw OCA], [http://pdbe.org/6rlw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rlw RCSB], [http://www.ebi.ac.uk/pdbsum/6rlw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rlw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN]] Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN]] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Masuyer G]] | + | [[Category: Masuyer, G]] |
| - | [[Category: Stenmark P]] | + | [[Category: Stenmark, P]] |
| + | [[Category: Cancer]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Dna repair]] | ||
| + | [[Category: Small molecule inhibitor]] | ||
Revision as of 08:07, 2 December 2020
Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with inhibitor TH5487
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