6tru

<StructureSection load='6tru' size='340' side='right'caption='[[6tru]], [[Resolution|resolution]] 2.80&Aring;' scene=''>

<table><tr><td colspan='2'>[[6tru]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TRU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TRU FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTHT_0044720 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tru OCA], [http://pdbe.org/6tru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tru RCSB], [http://www.ebi.ac.uk/pdbsum/6tru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tru ProSAT]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/G0S965_CHATD G0S965_CHATD]] Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.[RuleBase:RU364024] Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.[ARBA:ARBA00002817]

[[Category: Chatd]]

[[Category: Kisker, C]]

[[Category: Koelmel, W]]

[[Category: Kuper, J]]

[[Category: Schoenwetter, E]]

[[Category: Transcription]]