7ahk
From Proteopedia
(Difference between revisions)
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==Crystal structure of the outward-facing state of the substrate-free Na+-only bound glutamate transporter homolog GltPh== | ==Crystal structure of the outward-facing state of the substrate-free Na+-only bound glutamate transporter homolog GltPh== | ||
| - | <StructureSection load='7ahk' size='340' side='right'caption='[[7ahk]]' scene=''> | + | <StructureSection load='7ahk' size='340' side='right'caption='[[7ahk]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AHK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7AHK FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ahk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AHK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7AHK FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7ahk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ahk OCA], [http://pdbe.org/7ahk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7ahk RCSB], [http://www.ebi.ac.uk/pdbsum/7ahk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7ahk ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PH1295 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 'Pyrococcus shinkaii'])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7ahk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ahk OCA], [http://pdbe.org/7ahk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7ahk RCSB], [http://www.ebi.ac.uk/pdbsum/7ahk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7ahk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLT_PYRHO GLT_PYRHO]] Sodium-dependent, high-affinity amino acid transporter that mediates aspartate uptake (PubMed:17435767, PubMed:19380583, PubMed:17230192, Ref.11). Has only very low glutamate transport activity (PubMed:19380583, PubMed:17230192). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions, resulting in electrogenic transport (PubMed:17435767, PubMed:19380583, Ref.11). Na(+) binding enhances the affinity for aspartate (PubMed:19380583, Ref.11). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:17435767). In contrast to mammalian homologs, transport does not depend on pH or K(+) ions (PubMed:19380583).<ref>PMID:17230192</ref> <ref>PMID:17435767</ref> <ref>PMID:19380583</ref> [PDB:4P19] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Pyrococcus shinkaii]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Alleva C]] | + | [[Category: Alleva, C]] |
| - | [[Category: Astashkin A]] | + | [[Category: Astashkin, A]] |
| - | [[Category: Fahlke C]] | + | [[Category: Fahlke, C]] |
| - | [[Category: Gordeliy V]] | + | [[Category: Gordeliy, V]] |
| - | [[Category: Kovalev K]] | + | [[Category: Kovalev, K]] |
| - | [[Category: Machtens J | + | [[Category: Machtens, J P]] |
| + | [[Category: Aminoacid transport]] | ||
| + | [[Category: Glutamate transporter]] | ||
| + | [[Category: Homologue]] | ||
| + | [[Category: Membrane protein]] | ||
Revision as of 08:19, 2 December 2020
Crystal structure of the outward-facing state of the substrate-free Na+-only bound glutamate transporter homolog GltPh
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