TRAIL

From Proteopedia

Revision as of 09:36, 7 December 2020

spinqualitylabelsall models Human TRAIL trimer residues 114-281 (grey, light green, yellow) complex with death receptor-5 extracellular domain (dark blue, dark green, olive), Zn+2 (grey) and Cl-1 (green) ions, 1d0g Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function TRAIL (TNF-related apoptosis-inducing ligand) or TNF ligand superfamily 10 functions as a ligand in the process of apoptosis[1]. TRAIL binds to death receptors DR4, DR5, DcR1 and DcR2. For details see Molecular Playground/TRAIL. (1d0g). . Disease TRAIL concentrations are reduced in rheumatoid arthritis[2].

3D Structures of TRAIL

Updated on 07-December-2020

1d0g, 1d4v, 1du3, 5cir - hTRAIL extracellular domain + DR5 extracellular domain - human
1dg6 – hTRAIL jelly-roll domain
1d2q - hTRAIL extracellular domain
4n90 - hTRAIL extracellular domain + DR5 extracellular domain + antibody

References

1. ↑ Daniels RA, Turley H, Kimberley FC, Liu XS, Mongkolsapaya J, Ch'En P, Xu XN, Jin BQ, Pezzella F, Screaton GR. Expression of TRAIL and TRAIL receptors in normal and malignant tissues. Cell Res. 2005 Jun;15(6):430-8. PMID:15987601 doi:http://dx.doi.org/10.1038/sj.cr.7290311
2. ↑ Dessein PH, Lopez-Mejias R, Ubilla B, Genre F, Corrales A, Hernandez JL, Ferraz-Amaro I, Tsang L, Pina T, Llorca J, Blanco R, Gonzalez-Juanatey C, Gonzalez-Gay MA. TNF-related apoptosis-inducing ligand and cardiovascular disease in rheumatoid arthritis. Clin Exp Rheumatol. 2015 Jul-Aug;33(4):491-7. Epub 2015 May 11. PMID:25962765