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Function of your Protein

Biological relevance and broader implications

SidA is from Aspergillus fumigatus and is a fungal disease drug target that is involved in the production of hydromate-containing siderophores, that are used by a pathogen to take iron. This protein affects the lungs and can be fatal in humans and animals. Because iron is the host organism, it is sequestered by the iron-building proteins which makes it a restricted nutrient for SidA. This is relevant because they are finding new information about configurational dynamics in flavin-dependent monooxygenases. We are using this to understand all of the different active sites and their conformations during the catalytic cycle. This results in the fine-tuning of inhibitor discovery efforts.

Important amino acids

Structural highlights

Other important features

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