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Adhesins, commonly found on the surface of bacteria, aid in binding or adhering the bacteria to other cells. This is normally the beginning of an infection as the bacteria can bind to a host cell and potentially start a cascade of events within the host cell that leads to the bacteria invading^[1]. Various bacteria have various types of adhesin proteins, but this page looks specifically at epithelial adhesins, particularly one found in Candida glabrata which causes infections most often in immunosuppressed patients^[2] and can lead to deadly bloodstream infections.

Function of your Protein

Adhesins are used for binding cells together, commonly found helping pathogens bind to host cells. This specific adhesin has a ligand of

The protein is mainly made of antiparallel beta sheets, with the loops connecting the sheets making up the most critical parts of the active site. Two loops responsible for binding to the calcium ion, CBL1 and CLB2, are closer to the rest of the protein, and loops L1-L3 are further out - some of these loops are highly conserved between different adhesins, some are very variable.

Biological relevance and broader implications

Important amino acids

Structural highlights

Other important features

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.