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Function of your Protein

Biological relevance and broader implications

SidA is from Aspergillus fumigatus and is a fungal disease drug target that is involved in the production of hydromate-containing siderophores, that are used by a pathogen to take iron. This protein affects the lungs and can be fatal in humans and animals. Because iron is the host organism, it is sequestered by the iron-building proteins which makes it a restricted nutrient for SidA. This is relevant because they are finding new information about configurational dynamics in flavin-dependent monooxygenases. We are using this to understand all of the different active sites and their conformations during the catalytic cycle. This results in the fine-tuning of inhibitor discovery efforts.

Important amino acids

The important amino acids to pay attention to are Tyr324, Tyr276, Ser325, Asn323, and Asn275. Tyr324 is important because it moves over by 10A and shifts away from the active site. We have a triad which consists of Asn323, -FTyr324, and -Ser325. .

Structural highlights

. The ligands it does have are NADPH and FAD and they're bound, just not to the substrate

Other important features

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