1d8h

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[[Image:1d8h.gif|left|200px]]
[[Image:1d8h.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1d8h |SIZE=350|CAPTION= <scene name='initialview01'>1d8h</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1d8h", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Polynucleotide_5'-phosphatase Polynucleotide 5'-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.33 3.1.3.33] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1d8h| PDB=1d8h | SCENE= }}
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|RELATEDENTRY=[[1d8i|1D8I]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d8h OCA], [http://www.ebi.ac.uk/pdbsum/1d8h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d8h RCSB]</span>
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}}
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'''X-RAY CRYSTAL STRUCTURE OF YEAST RNA TRIPHOSPHATASE IN COMPLEX WITH SULFATE AND MANGANESE IONS.'''
'''X-RAY CRYSTAL STRUCTURE OF YEAST RNA TRIPHOSPHATASE IN COMPLEX WITH SULFATE AND MANGANESE IONS.'''
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[[Category: Shuman, S.]]
[[Category: Shuman, S.]]
[[Category: Wang, L K.]]
[[Category: Wang, L K.]]
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[[Category: beta subunit]]
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[[Category: Beta subunit]]
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[[Category: catalytic domain]]
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[[Category: Catalytic domain]]
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[[Category: dimer]]
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[[Category: Dimer]]
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[[Category: manganese/sulfate complex]]
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[[Category: Manganese/sulfate complex]]
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[[Category: mrna capping]]
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[[Category: Mrna capping]]
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[[Category: mrna processing]]
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[[Category: Mrna processing]]
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[[Category: nuclear protein beta barrel]]
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[[Category: Nuclear protein beta barrel]]
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[[Category: polynucleotide 5'-triphosphatase]]
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[[Category: Polynucleotide 5'-triphosphatase]]
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[[Category: rna triphosphatase]]
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[[Category: Rna triphosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:34:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:36:46 2008''
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Revision as of 10:34, 2 May 2008

Image:1d8h.gif

Template:STRUCTURE 1d8h

X-RAY CRYSTAL STRUCTURE OF YEAST RNA TRIPHOSPHATASE IN COMPLEX WITH SULFATE AND MANGANESE IONS.


Overview

RNA triphosphatase is an essential mRNA processing enzyme that catalyzes the first step in cap formation. The 2.05 A crystal structure of yeast RNA triphosphatase Cet1p reveals a novel active site fold whereby an eight-stranded beta barrel forms a topologically closed triphosphate tunnel. Interactions of a sulfate in the center of the tunnel with a divalent cation and basic amino acids projecting into the tunnel suggest a catalytic mechanism that is supported by mutational data. Discrete surface domains mediate Cet1p homodimerization and Cet1p binding to the guanylyltransferase component of the capping apparatus. The structure and mechanism of fungal RNA triphosphatases are completely different from those of mammalian mRNA capping enzymes. Hence, RNA triphosphatase presents an ideal target for structure-based antifungal drug discovery.

About this Structure

1D8H is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of yeast RNA triphosphatase: an essential component of the mRNA capping apparatus., Lima CD, Wang LK, Shuman S, Cell. 1999 Nov 24;99(5):533-43. PMID:10589681 Page seeded by OCA on Fri May 2 13:34:08 2008

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