6l77
From Proteopedia
(Difference between revisions)
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| - | == | + | ==Crystal structure of MS5 from Brassica napus== |
| - | <StructureSection load='6l77' size='340' side='right'caption='[[6l77]]' scene=''> | + | <StructureSection load='6l77' size='340' side='right'caption='[[6l77]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L77 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6L77 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6l77]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brana Brana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L77 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6L77 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6l77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l77 OCA], [http://pdbe.org/6l77 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l77 RCSB], [http://www.ebi.ac.uk/pdbsum/6l77 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l77 ProSAT]</span></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MS5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3708 BRANA])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6l77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l77 OCA], [http://pdbe.org/6l77 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l77 RCSB], [http://www.ebi.ac.uk/pdbsum/6l77 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l77 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | MS5 is a meiosis-related protein belonging to the Brassicaceae-specific domain of unknown function family and characterized by the MS5 superfamily domain (MSD). In this study, we elucidated the three-dimensional crystal structure and potential biochemical function of the MSD. It was observed that the MSD adopts a cystatin-like fold, mainly consisting of a central alpha-helix and four- or five-stranded antiparallel beta-sheets that wrap around it. However, unlike cystatins, which inhibit cysteine proteases, the MSD displayed allosteric activation of papain. We believe that our study provides insight into novel mechanisms of proteolytic enzyme regulation and may serve as a basis for functional studies of the MS5 family proteins in plants. | ||
| + | |||
| + | Structural analysis of the meiosis-related protein MS5 reveals non-canonical papain enhancement by cystatin-like folds.,Wang X, Gao Y, Guan Z, Xie Z, Zhang D, Yin P, Yang G, Hong D, Xin Q FEBS Lett. 2020 Aug;594(15):2462-2471. doi: 10.1002/1873-3468.13817. Epub 2020, May 26. PMID:32415887<ref>PMID:32415887</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6l77" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Brana]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Guan, Z Y]] |
| + | [[Category: Wang, X]] | ||
| + | [[Category: Yin, P]] | ||
| + | [[Category: Cystatin-like]] | ||
| + | [[Category: Unknown function]] | ||
Revision as of 06:45, 9 December 2020
Crystal structure of MS5 from Brassica napus
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