This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

1pdu

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Revision as of 07:28, 9 December 2020

Ligand-binding domain of Drosophila orphan nuclear receptor DHR38

Structural highlights

1pdu is a 2 chain structure with sequence from Drome. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	HR38 (DROME)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[HR38_DROME] Binds to NGFI-B response elements. Plays an important role in late stages of epidermal metamorphosis.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Ecdysteroid pulses trigger the major developmental transitions during the Drosophila life cycle. These hormonal responses are thought to be mediated by the ecdysteroid receptor (EcR) and its heterodimeric partner Ultraspiracle (USP). We provide evidence for a second ecdysteroid signaling pathway mediated by DHR38, the Drosophila ortholog of the mammalian NGFI-B subfamily of orphan nuclear receptors. DHR38 also heterodimerizes with USP, and this complex responds to a distinct class of ecdysteroids in a manner that is independent of EcR. This response is unusual in that it does not involve direct binding of ecdysteroids to either DHR38 or USP. X-ray crystallographic analysis of DHR38 reveals the absence of both a classic ligand binding pocket and coactivator binding site, features that seem to be common to all NGFI-B subfamily members. Taken together, these data reveal the existence of a separate structural class of nuclear receptors that is conserved from fly to humans.

The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway.,Baker KD, Shewchuk LM, Kozlova T, Makishima M, Hassell A, Wisely B, Caravella JA, Lambert MH, Reinking JL, Krause H, Thummel CS, Willson TM, Mangelsdorf DJ Cell. 2003 Jun 13;113(6):731-42. PMID:12809604^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Baker KD, Shewchuk LM, Kozlova T, Makishima M, Hassell A, Wisely B, Caravella JA, Lambert MH, Reinking JL, Krause H, Thummel CS, Willson TM, Mangelsdorf DJ. The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway. Cell. 2003 Jun 13;113(6):731-42. PMID:12809604

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pdu"

@@ Line 1: / Line 1: @@
 ==Ligand-binding domain of Drosophila orphan nuclear receptor DHR38==
-<StructureSection load='1pdu' size='340' side='right' caption='[[1pdu]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+<StructureSection load='1pdu' size='340' side='right'caption='[[1pdu]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1pdu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PDU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PDU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1pdu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PDU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1PDU FirstGlance]. <br>
 </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HR38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pdu OCA], [http://pdbe.org/1pdu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pdu RCSB], [http://www.ebi.ac.uk/pdbsum/1pdu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pdu ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1pdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pdu OCA], [http://pdbe.org/1pdu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pdu RCSB], [http://www.ebi.ac.uk/pdbsum/1pdu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pdu ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 33: / Line 33: @@
 </StructureSection>
 [[Category: Drome]]
+[[Category: Large Structures]]
 [[Category: Baker, K D]]
 [[Category: Caravella, J A]]

1pdu

From Proteopedia

Revision as of 07:28, 9 December 2020

Ligand-binding domain of Drosophila orphan nuclear receptor DHR38

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox