1dab
From Proteopedia
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'''The Structure of Bordetella Pertussis Virulence Factor P.69 Pertactin''' | '''The Structure of Bordetella Pertussis Virulence Factor P.69 Pertactin''' | ||
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[[Category: Fairweather, N F.]] | [[Category: Fairweather, N F.]] | ||
[[Category: Isaacs, N W.]] | [[Category: Isaacs, N W.]] | ||
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Revision as of 10:37, 2 May 2008
The Structure of Bordetella Pertussis Virulence Factor P.69 Pertactin
Overview
A new generation of whooping-cough vaccines contain P.69 pertactin, a surface-exposed domain of an outer membrane protein expressed by the virulent bacterium Bordetella pertussis. This protein is a virulence factor that mediates adhesion to target mammalian cells, a reaction that is in part mediated by an RGD sequence. The X-ray crystal structure of P.69 pertactin has been determined to 2.5 A. The protein fold consists of a 16-stranded parallel beta-helix with a V-shaped cross-section, and is the largest beta-helix known to date. Several between-strand weakly conserved amino-acid repeats form internal and external ladders. The structure appears as a helix from which several loops protrude, which contain sequence motifs associated with the biological activity of the protein. One particular (GGXXP)5 sequence is located directly after the RGD motif, and may mediate interaction with epithelial cells. The carboxy-terminal region of P.69 pertactin incorporates a (PQP)5 motif loop containing the major immunoprotective epitope.
About this Structure
1DAB is a Single protein structure of sequence from Bordetella pertussis. Full crystallographic information is available from OCA.
Reference
Structure of Bordetella pertussis virulence factor P.69 pertactin., Emsley P, Charles IG, Fairweather NF, Isaacs NW, Nature. 1996 May 2;381(6577):90-2. PMID:8609998 Page seeded by OCA on Fri May 2 13:37:27 2008
