1daw

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[[Image:1daw.jpg|left|200px]]
[[Image:1daw.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1daw |SIZE=350|CAPTION= <scene name='initialview01'>1daw</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1daw", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1daw| PDB=1daw | SCENE= }}
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|RELATEDENTRY=[[1a6o|1A6O]], [[1day|1DAY]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1daw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1daw OCA], [http://www.ebi.ac.uk/pdbsum/1daw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1daw RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-AMPPNP'''
'''CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-AMPPNP'''
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[[Category: Puetter, M.]]
[[Category: Puetter, M.]]
[[Category: Schomburg, D.]]
[[Category: Schomburg, D.]]
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[[Category: binary complex]]
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[[Category: Binary complex]]
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[[Category: dual-cosubstrate specificity]]
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[[Category: Dual-cosubstrate specificity]]
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[[Category: protein kinase ck2]]
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[[Category: Protein kinase ck2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:38:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:37:59 2008''
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Revision as of 10:38, 2 May 2008

Image:1daw.jpg

Template:STRUCTURE 1daw

CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-AMPPNP


Overview

The structures of the catalytic subunit of protein kinase CK2 from Zea mays complexed with Mg2+ and with analogs of ATP or GTP were determined to 2.2 A resolution. Unlike most other protein kinases, CK2 from various sources shows 'dual-cosubstrate specificity', that is, the ability to efficiently use either ATP or GTP as a cosubstrate. The structures of these complexes demonstrate that water molecules are critical to switch the active site of CK2 from an ATP- to a GTP-compatible state. An understanding of the structural basis of dual-cosubstrate specificity may help in the design of drugs that target CK2 or other kinases with this property.

About this Structure

1DAW is a Single protein structure of sequence from Zea mays. Full crystallographic information is available from OCA.

Reference

GTP plus water mimic ATP in the active site of protein kinase CK2., Niefind K, Putter M, Guerra B, Issinger OG, Schomburg D, Nat Struct Biol. 1999 Dec;6(12):1100-3. PMID:10581548 Page seeded by OCA on Fri May 2 13:38:35 2008

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