1db1

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[[Image:1db1.gif|left|200px]]
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{{Structure
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|PDB= 1db1 |SIZE=350|CAPTION= <scene name='initialview01'>1db1</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1db1", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=VDX:5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL'>VDX</scene>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1db1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1db1 OCA], [http://www.ebi.ac.uk/pdbsum/1db1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1db1 RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE NUCLEAR RECEPTOR FOR VITAMIN D COMPLEXED TO VITAMIN D'''
'''CRYSTAL STRUCTURE OF THE NUCLEAR RECEPTOR FOR VITAMIN D COMPLEXED TO VITAMIN D'''
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[[Category: Rochel, N.]]
[[Category: Rochel, N.]]
[[Category: Wurtz, J M.]]
[[Category: Wurtz, J M.]]
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[[Category: complex]]
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[[Category: Complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:38:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:38:10 2008''
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Revision as of 10:38, 2 May 2008

Image:1db1.gif


PDB ID 1db1

Drag the structure with the mouse to rotate
1db1, resolution 1.80Å ()
Ligands:
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE NUCLEAR RECEPTOR FOR VITAMIN D COMPLEXED TO VITAMIN D


Overview

The action of 1 alpha, 25-dihydroxyvitamin D3 is mediated by its nuclear receptor (VDR), a ligand-dependent transcription regulator. We report the 1.8 A resolution crystal structure of the complex between a VDR ligand-binding domain (LBD) construct lacking the highly variable VDR-specific insertion domain and vitamin D. The construct exhibits the same binding affinity for vitamin D and transactivation ability as the wild-type protein, showing that the N-terminal part of the LBD is essential for its structural and functional integrity while the large insertion peptide is dispensable. The structure reveals the active conformation of the bound ligand and allows understanding of the different binding properties of some synthetic analogs.

About this Structure

1DB1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand., Rochel N, Wurtz JM, Mitschler A, Klaholz B, Moras D, Mol Cell. 2000 Jan;5(1):173-9. PMID:10678179 Page seeded by OCA on Fri May 2 13:38:50 2008

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