7jlv

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==Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ==
==Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ==
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<StructureSection load='7jlv' size='340' side='right'caption='[[7jlv]]' scene=''>
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<StructureSection load='7jlv' size='340' side='right'caption='[[7jlv]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JLV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JLV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7jlv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Nicbe Nicbe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JLV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JLV FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jlv OCA], [http://pdbe.org/7jlv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jlv RCSB], [http://www.ebi.ac.uk/pdbsum/7jlv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jlv ProSAT]</span></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ROQ1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4100 NICBE])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ADP-ribosyl_cyclase/cyclic_ADP-ribose_hydrolase ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.6 3.2.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jlv OCA], [http://pdbe.org/7jlv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jlv RCSB], [http://www.ebi.ac.uk/pdbsum/7jlv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jlv ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ROQ1_NICBE ROQ1_NICBE]] Disease resistance (R) protein that specifically recognizes the Xanthomonas and Pseudomonas effector proteins XopQ and HopQ1, and triggers cell death (PubMed:28891100). Acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death (PubMed:31439792).<ref>PMID:28891100</ref> <ref>PMID:31439792</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Plants and animals detect pathogen infection using intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) that directly or indirectly recognize pathogen effectors and activate an immune response. How effector sensing triggers NLR activation remains poorly understood. Here we describe the 3.8-angstrom-resolution cryo-electron microscopy structure of the activated ROQ1 (recognition of XopQ 1), an NLR native to Nicotiana benthamiana with a Toll-like interleukin-1 receptor (TIR) domain bound to the Xanthomonas euvesicatoria effector XopQ (Xanthomonas outer protein Q). ROQ1 directly binds to both the predicted active site and surface residues of XopQ while forming a tetrameric resistosome that brings together the TIR domains for downstream immune signaling. Our results suggest a mechanism for the direct recognition of effectors by NLRs leading to the oligomerization-dependent activation of a plant resistosome and signaling by the TIR domain.
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Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ.,Martin R, Qi T, Zhang H, Liu F, King M, Toth C, Nogales E, Staskawicz BJ Science. 2020 Dec 4;370(6521). pii: 370/6521/eabd9993. doi:, 10.1126/science.abd9993. PMID:33273074<ref>PMID:33273074</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7jlv" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: King M]]
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[[Category: Nicbe]]
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[[Category: Lui F]]
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[[Category: King, M]]
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[[Category: Martin R]]
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[[Category: Lui, F]]
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[[Category: Nogales E]]
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[[Category: Martin, R]]
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[[Category: Qi T]]
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[[Category: Nogales, E]]
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[[Category: Staskawicz BJ]]
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[[Category: Qi, T]]
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[[Category: Toth C]]
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[[Category: Staskawicz, B J]]
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[[Category: Zhang H]]
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[[Category: Toth, C]]
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[[Category: Zhang, H]]
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[[Category: Effector]]
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[[Category: Immune system]]
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[[Category: Lrr]]
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[[Category: Nb-arc]]
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[[Category: Plant immunity]]
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[[Category: Resistosome]]
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[[Category: Tir]]

Revision as of 13:01, 16 December 2020

Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ

PDB ID 7jlv

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