1dbr

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dbr OCA], [http://www.ebi.ac.uk/pdbsum/1dbr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dbr RCSB]</span>
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'''HYPOXANTHINE GUANINE XANTHINE'''
'''HYPOXANTHINE GUANINE XANTHINE'''
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[[Category: Schumacher, M A.]]
[[Category: Schumacher, M A.]]
[[Category: Ullman, B.]]
[[Category: Ullman, B.]]
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[[Category: glycosyltransferase]]
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[[Category: Glycosyltransferase]]
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[[Category: purine salvage]]
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[[Category: Purine salvage]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:40:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:38:27 2008''
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Revision as of 10:40, 2 May 2008

Image:1dbr.jpg

Template:STRUCTURE 1dbr

HYPOXANTHINE GUANINE XANTHINE


Overview

Crystal structures of substrate-free and XMP-soaked hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) of the opportunistic pathogen Toxoplasma gondii have been determined to 2.4 and 2.9 A resolution, respectively. HGXPRTase displays the conserved PRTase fold. In the structure of the enzyme bound to its product, a long flexible loop (residues 115-126) is located away from the active site. Comparison to the substrate-free structure reveals a striking relocation of the loop, which is poised to cover the catalytic pocket, thus providing a mechanism by which the HG(X)PRTases shield their oxocarbonium transition states from nucleophilic attack by the bulk solvent. The conserved Ser 117-Tyr 118 dipeptide within the loop is brought to the active site, completing the ensemble of catalytic residues.

About this Structure

1DBR is a Single protein structure of sequence from Toxoplasma gondii. Full crystallographic information is available from OCA.

Reference

Crystal structures of Toxoplasma gondii HGXPRTase reveal the catalytic role of a long flexible loop., Schumacher MA, Carter D, Ross DS, Ullman B, Brennan RG, Nat Struct Biol. 1996 Oct;3(10):881-7. PMID:8836106 Page seeded by OCA on Fri May 2 13:40:00 2008

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