Tubulin tyrosine ligase

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*Tubulin tyrosine ligase complex with tubulin
*Tubulin tyrosine ligase complex with tubulin
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**[[5jqg]], [[5xp3]] – pTTL + rSTM + tubulin + GTP + GDP + ATP derivative - pig <br />
+
**[[5jqg]], [[5xp3]], [[6i5c]], [[4i55]], [[6s9e]], [[6gze]], [[4wbn]] – cTTL + STM + tubulin + GTP + GDP + ATP derivative - chicken <br />
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**[[4iij]] – cTTL + rSTM + tubulin + GTP + GDP - chicken<br />
+
**[[4iij]] – cTTL + STM + tubulin + GTP + GDP <br />
-
**[[4ihj]] – cTTL + rSTM + tubulin + GTP + GDP + ADP <br />
+
**[[4ihj]] – cTTL + STM + tubulin + GTP + GDP + ADP <br />
-
**[[6i5c]], [[4i55]], [[6s9e]], [[6gze]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative <br />
+
**[[5ng1]], [[5nfz]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + stabilizer <br />
*Tubulin tyrosine ligase complex with tubulin and inhibitor
*Tubulin tyrosine ligase complex with tubulin and inhibitor
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**[[5iyz]], [[5j2t]], [[5j2u]], [[5la6]], [[5bmv]], [[5jh7]] – bTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor - bovine<br />
+
**[[5iyz]], [[5j2t]], [[5j2u]], [[5la6]], [[5bmv]], [[5jh7]], [[4tv9]], [[4yj2]], [[4yj3]], [[2xrp]], [[7jfr]] – cTTL + STM + tubulin + GTP + GDP + ATP derivative + auristatin anti-mitotics<br />
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**[[4zhq]], [[4zi7]], [[4zol]], [[5c8y]], [[5fnv]], [[5m7g]], [[5m8d]], [[5m8g]], [[5xlt]], [[5lov]], [[5lyj]], [[5m7e]], [[5njh]], [[5lxs]] – pTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor <br />
+
**[[5xkf]], [[5xkg]] – cTTL + STM + tubulin + GTP + GDP + inhibitor<br />
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**[[5iyz]] – pTTL + rSTM + tubulin + GTP + GDP + ATP derivative + auristatin <br />
+
**[[4o2a]], [[5fnv]], [[5ca1]] – cTTL + STM + tubulin + GTP + GDP + ADP + inhibitor<br />
-
**[[5cb4]] – bpTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor – bearded pig<br />
+
**[[4o4l]], [[4tuy]], [[4tv8]], [[4yj2]], [[4yj3]], [[5j2t]], [[5xiw]], ]], [[6fii]], [[6fjm]], [[6gf3]], [[5jh7]], [[5bmv]], [[5la6]], [[5osk]], [[5jvd]], [[5gon]], [[5xlt]], [[5xaf]], [[5xag]], [[5jcb]], [[5c8y]], [[6d88]], [[6br1]], [[6brf]], [[6bry]], [[6bs2]], [[6pc4]], [[5xkg]], [[5xkh]], [[5xke]], [[5xkf]], [[4o4l]], [[4tuy]], [[4tv8]], [[4yj2]], [[4yj3]] – cTTL + STM + tubulin + GTP + GDP + anti-cancer drugs<br />
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**[[5xkf]], [[5xkg]] – cTTL + rSTM + tubulin + GTP + GDP + inhibitor<br />
+
**[[4o4h]], [[4o4j]], [[4o4i]], [[5c8y]], [[5cb4]], [[5ca1]], [[5bmv]], [[5jh7]], [[5lxt]], [[4i4t]], [[5osk]], [[5xlt]], [[5xlz]], [[5mw1]], [[6fii]], [[6fjm]], [[5xag]], [[4i50]], [[6knz]], [[6gj4]], [[6gf3]], [[6f7c]], [[5yl4]], [[5cb4]], [[5jcb]] – cTTL + STM + tubulin + GTP + GDP + ATP derivative + anti-cancer drug<br />
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**[[4o2a]], [[5fnv]], [[5ca1]] – cTTL + rSTM + tubulin + GTP + GDP + ADP + inhibitor<br />
+
**[[6ses]] – cTTL + STM + tubulin + GTP + GDP + ATP derivative + drug<br />
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**[[5ng1]], [[5nfz]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + stabilizer <br />
+
**[[5xlz]] - cTTL + STM + tubulin + GTP + GDP + ATP derivative + + anthracene derivative <br />
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**[[4o4l]], [[4tuy]], [[4tv8]], [[4yj2]], [[4yj3]], [[5j2t]], [[5xiw]] – cTTL + rSTM + tubulin + GTP + GDP + anti-cancer drugs<br />
+
**[[6qqn]], [[6k9v]], [[6jcj]], [[6hx8]], [[6eg5]], [[6agk]], [[5zxh]], [[5z4u]], [[5z4p]], [[5yz3]], [[5h7o]], [[6o61]], [[6o5n]], [[6o5m]], [[6nng]], [[6fjf]], [[5cb4]], [[5xhc]], [[5xi5]], [[5xi7]], [[6n47]], [[5yls]], [[5jcb]], [[5ca0]], [[5yl2]], [[5ylj]], [[6fkl]], [[6fkj]], [[6kpp]], [[6y6d]], [[5yl2]], [[5ylj]], [[6br1]], [[6brf]], [[6bry]], [[6bs2]], [[6d88]], [[6fjf]], [[6fkj]], [[5xhc]], [[5xi5]], [[5xi7]], [[4zhq]], [[4zi7]], [[4zol]], [[5c8y]], [[5fnv]], [[5m7g]], [[5m8d]], [[5m8g]], [[5xlt]], [[5lov]], [[5lyj]], [[5m7e]], [[5njh]], [[5lxs]] – cTTL + STM + tubulin + GTP + GDP + ATP derivative + inhibitor<br />
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**[[4o4h]], [[4o4j]], [[4o4i]], [[5c8y]], [[5cb4]], [[5ca1]], [[5bmv]], [[5jh7]], [[5lxt]], [[4i4t]], [[5osk]], [[5xlt]], [[5xlz]], [[5mw1]], [[6fii]], [[6fjm]], [[5xag]], [[4i50]], [[6knz]], [[6gj4]], [[6gf3]], [[6f7c]], [[5yl4]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + anti-cancer drug<br />
+
**[[5xiw]] – cTTL + STM + tubulin + GTP + GDP + anti-gout drug<br />
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**[[6qqn]], [[6k9v]], [[6jcj]], [[6hx8]], [[6eg5]], [[6agk]], [[5zxh]], [[5z4u]], [[5z4p]], [[5yz3]], [[5h7o]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor<br />
+
**[[4o2b]], [[5lp6]] – cTTL + STM + tubulin + GTP + GDP + ATP derivative + anti-gout drug<br />
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**[[6o61]], [[6o5n]], [[6o5m]], [[6nng]] – cTTL + hSTM + tubulin + GTP + GDP + ATP derivative + inhibitor<br />
+
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**[[5jcb]] – cTTL + pSTM + tubulin + GTP + GDP + ATP derivative + anti-cancer drug<br />
+
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**[[4o2b]], [[5lp6]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + anti-gout drug<br />
+
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**[[5yl2]], [[5ylj]], [[5yls]], [[6br1]], [[6brf]], [[6bry]], [[6bs2]], [[6d88]], [[6fjf]], [[6fkj]], [[6fkl]], [[5xhc]], [[5xi5]], [[5xi7]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor<br />
+
}}
}}

Revision as of 08:46, 24 December 2020

Tubulin tyrosine ligase (cyan) complex with α-tubulin (grey and pink), β-tubulin (green and yellow), stathmin (magenta), MES, GTP, Ca+2, Cl- and Mg+2 ions (PDB code 4iij)

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3D Structures of tubulin tyrosine ligase

Updated on 24-December-2020

References

  1. ↑ Idriss HT. Phosphorylation of tubulin tyrosine ligase: a potential mechanism for regulation of alpha-tubulin tyrosination. Cell Motil Cytoskeleton. 2000 May;46(1):1-5. PMID:10842328 doi:<1::AID-CM1>3.0.CO;2-6 http://dx.doi.org/10.1002/(SICI)1097-0169(200005)46:1<1::AID-CM1>3.0.CO;2-6
  2. ↑ Szyk A, Piszczek G, Roll-Mecak A. Tubulin tyrosine ligase and stathmin compete for tubulin binding in vitro. J Mol Biol. 2013 Jul 24;425(14):2412-4. doi: 10.1016/j.jmb.2013.04.017. Epub 2013, Apr 25. PMID:23624152 doi:http://dx.doi.org/10.1016/j.jmb.2013.04.017
  3. ↑ Lafanechere L, Courtay-Cahen C, Kawakami T, Jacrot M, Rudiger M, Wehland J, Job D, Margolis RL. Suppression of tubulin tyrosine ligase during tumor growth. J Cell Sci. 1998 Jan;111 ( Pt 2):171-81. PMID:9405300
  4. ↑ Prota AE, Magiera MM, Kuijpers M, Bargsten K, Frey D, Wieser M, Jaussi R, Hoogenraad CC, Kammerer RA, Janke C, Steinmetz MO. Structural basis of tubulin tyrosination by tubulin tyrosine ligase. J Cell Biol. 2013 Feb 4;200(3):259-70. doi: 10.1083/jcb.201211017. Epub 2013 Jan , 28. PMID:23358242 doi:http://dx.doi.org/10.1083/jcb.201211017

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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