6lbw

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lbw OCA], [http://pdbe.org/6lbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lbw RCSB], [http://www.ebi.ac.uk/pdbsum/6lbw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lbw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lbw OCA], [http://pdbe.org/6lbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lbw RCSB], [http://www.ebi.ac.uk/pdbsum/6lbw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lbw ProSAT]</span></td></tr>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Metal-mediated base pairs have widespread applications, such as in DNA-metal nanodevices and sensors. Here, we focused on their sugar conformation in duplexes and observed the crystallographic structure of the non-canonical DNA/DNA duplex containing 2'-O,4'-C-methylene bridged nucleic acid in the presence of AgI ions. The X-ray crystallographic structure was successfully obtained at a resolution of 1.5 A. A novel type of AgI-mediated base pair between the N1 positions of anti-conformation of adenines in the duplex was observed. In the central non-canonical region, a hexad nucleobase structure containing AgI-mediated base pairs between the N7 positions of guanines was formed. A highly bent non-canonical structure was formed at the origin of AgI-mediated base pairs in the central region. The bent duplex structure induced by the addition of AgI ions might become a powerful tool for dynamic structural changes in DNA nanotechnology applications.
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Crystallographic Structure of Novel Types of AgI-Mediated Base Pairs in Non-canonical DNA Duplex Containing 2'-O,4'-C-Methylene Bridged Nucleic Acids.,Nakagawa O, Aoyama H, Fujii A, Kishimoto Y, Obika S Chemistry. 2020 Dec 4. doi: 10.1002/chem.202004819. PMID:33274789<ref>PMID:33274789</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6lbw" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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</StructureSection>

Revision as of 10:48, 24 December 2020

Crystal structure of Ag-mediated base pairs in uncanonical DNA duplex

PDB ID 6lbw

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